Validation of the quantum Z-S Model by Means of the Interaction Between MW Fields and Zn -Protoporphyrin System

Abstract

The dynamics of the Zn-protoporphyrin IX has been assessed by means of molecular dynamics methods. The conformational rearrangements of the protoporphyrin atoms during the Zn²⁺ docking (sailing) into (from) the center of its binding site occurs in the picosecond scale, so that any microwave electromagnetic exposure can be considered as almost constant, with respect to the dynamics of the constituent atoms induced by the ion displacement. The computer simulation of the complexation process with and without a low-intensity electromagnetic field has demonstrated the inhibitory effect of the exposure on the complex formation.¹ This result has been confirmed experimentally at 2.45 GHz.^1,2 We have tested the predictive ability of the quantum Zeeman-Stark (Z-S) model³ of ligand binding against the Zn-protoporphyrin system.