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Enalapril (10 Mg/Day) in Systemic Sclerosis

One Year, Double Blind, Randomised Study (ESS-1): Echocardiographic Substudy—Three Months Follow-Up

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Rheumaderm

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 455))

Abstract

The ESS-1 study was designed to evaluate the long-term effects of the angiotensin converting enzyme inhibitor(ACEI) enalapril (10mg per day) on the cardio-pulmonary system in patients with scleroderma (SSc). We estimated changes in heart diameters, systolic and diastolic left ventricle function and mean values of pulmonary artery pressure after 3 months treatment. The study group comprise 41 patients with SSc. 18 patients received placebo and 23 ones were given enalapril. After 3 months of treatment we did not observe statistically significant differences in heart diameters and left ventricle systolic function parameters between treated group and placebo. Enalapril therapy did not affect left ventricle diastolic function, nevertheless differences in MVA were almost of statistical significance. Echocardiographic signs of pulmonary hypertension were found in 4 patients.

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Author information

Authors and Affiliations

  1. I Department of Internal Medicine, University School of Medicine, Lublin, Poland

    Andrej Biłan M.D., B. Makaruk, R. Palusiriski, J. Węglarz, S. Ostrowski, A. Witczak & J. Hanzlik

  2. Department of Dermatology, University School of Medicine, Lublin, Poland

    M. Chibowska & D. Krasowska

Authors
  1. Andrej Biłan M.D.
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  2. M. Chibowska
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  3. B. Makaruk
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  4. R. Palusiriski
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  5. J. Węglarz
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  6. S. Ostrowski
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  7. A. Witczak
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  8. J. Hanzlik
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  9. D. Krasowska
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Corresponding author

Correspondence to Andrej Biłan M.D. .

Editor information

Editors and Affiliations

  1. St. Luke’s Hospital, University of Malta Medical School, Malta, USA

    Carmel Mallia

  2. Jefferson Medical College, Thomas Jefferson Universit, Philadelphia, Pennsylvania, USA

    Jouni Uitto

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© 1999 Springer Science+Business Media New York

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Biłan, A. et al. (1999). Enalapril (10 Mg/Day) in Systemic Sclerosis. In: Mallia, C., Uitto, J. (eds) Rheumaderm. Advances in Experimental Medicine and Biology, vol 455. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4857-7_40

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  • DOI: https://doi.org/10.1007/978-1-4615-4857-7_40

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7203-5

  • Online ISBN: 978-1-4615-4857-7

  • eBook Packages: Springer Book Archive

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