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Generation of α1,3Galactosyltransferase Deficient Mice

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α-Gal and Anti-Gal

Part of the book series: Subcellular Biochemistry ((SCBI,volume 32))

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Abstract

All mammals, with the exception of apes, Old World monkeys, and humans possess a functional α1,3GT gene (Galili et al., 1990). Microsomal preparations from tissues of mammalian species as divergent as pigs, cows, New World monkey and mice all contain α1,3GT activity, capable of transferring Gal onto terminal N-acetyllactosamine containing glycolipids and glycoproteins (Thall et al., 1991a). As no other mammalian α 1,3GT genes have been cloned, it was assumed but not proven that this α 1,3GT gene is responsible for the synthesis of all α-gal epitopes in mammals other than apes, Old World Monkeys and humans. This enzymatic activity is distinct from the blood group B α1,3GT, which requires a terminal α 1,2-Fuc linked to N-acetyllactosamine as the acceptor structure and is active only in primates (Elices et al., 1986).

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  1. BioTransplant, Inc., Charlestown Navy Yard, Charlestown, Massachusetts, 02129, USA

    Aron D. Thall

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  1. MCP-Hahnemann School of Medicine, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania, USA

    Uri Galili

  2. Institute of Biomedicine, Caracas, Venezuela

    José Luis Avila

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Thall, A.D. (1999). Generation of α1,3Galactosyltransferase Deficient Mice. In: Galili, U., Avila, J.L. (eds) α-Gal and Anti-Gal. Subcellular Biochemistry, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4771-6_11

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  • DOI: https://doi.org/10.1007/978-1-4615-4771-6_11

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  • Print ISBN: 978-1-4613-7160-1

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