Abstract
Optical imaging spectroscopy is a technique for investigating the metabolic effects of brain activity (Jobsis et al., 1977; Malonek and Grinvald, 1996). It exploits the fact that the brain contains chromophores and these affect the spectra of light remitted (transmitted or reflected) from the brain’s surface. Spectrophotometry can be used to estimate changes in the relative proportions or volume fractions of these chromophores. The three most easily measured and common chromophores in brain are involved in the metabolic pathway satisfying the demands of active neurons. They are oxygenated and deoxygenated hemoglobin and the cytochromes, (particularly cytochrome oxidase) (Chance, 1991).
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Zheng, Y., Vuksanovic, B., Hou, Y., Mayhew, J. (1999). Monte Carlo Simulation and the Spectroscopic Analysis of the Response to Neural Stimulation in Brain. In: Eke, A., Delpy, D.T. (eds) Oxygen Transport to Tissue XXI. Advances in Experimental Medicine and Biology, vol 471. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4717-4_90
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DOI: https://doi.org/10.1007/978-1-4615-4717-4_90
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