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Molecular events that regulate cell proliferation: an approach for the development of new anticancer drugs

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

Cancer chemotherapy is the object of many fundamental and clinical researches. The development in molecular techniques and structural studies at the molecular level have led to the discovery of key proteins involved in the regulation of cell proliferation. This opened perspectives to characterize new anticancer drugs in order to reduce the limitations found with conventional drugs such as the lack of selectivity for cancer cells and resistance phenomena. This review presents the anticancer drugs in clinical investigations that target molecules involved in the signal transduction impairment, the cell cycle deregulation and the differentiation with comments on their mechanisms of action.

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Authors and Affiliations

  1. Laboratoire de Chimie Biologique, UMR n°111 du CNRS, 59655, Villeneuve d’Ascq Cedex, France

    Eve Damiens

  2. Laboratoire Cycle Cellulaire, Station Biologique, Place Georges Tessier, B.P. 74, 29682, Roscoff Cedex, France

    Eve Damiens

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  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Armelle Jézéquel  & 

  2. Centre National de la Recherche Scientifique, Université Paul Sabatier, Toulouse, France

    Bernard Ducommun

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Damiens, E. (2000). Molecular events that regulate cell proliferation: an approach for the development of new anticancer drugs. In: Meijer, L., Jézéquel, A., Ducommun, B. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4253-7_19

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