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Molecular Genetics of Alpha 2 Plasmin Inhibitor

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Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 281))

Abstract

α 2-Plasmin inhibitor (α 2PI), also called α 2-antiplasmin, is a plasma glycoprotein which rapidly inactivates plasmin proteolytic activity (1). Its molecular weight, deduced from the cDNA sequence and the carbohydrate content (14%), is ≅ 58 KD (2) whereas the molecular weight estimated by SDS-gel electrophoresis was 67 KD (1). The cause of the discrepancy is not known. Its concentration in human plasma was estimated to be 6.9 ± 0.6 mg/100 ml (3), which is estimated to be ≅ 1.2 μM on the assumption of MW 58KD. α 2PI is a serine proteinase inhibitor (serpin) which is able to inhibit several different “serine” proteinases, but is mainly playing a role as a primary inhibitor of plasmin-mediated fibrinolysis (4). Its congenital deficiency results in a lifelong severe hemorrhagic tendency due to premature degradation of hemostatic plugs by physiologically occurring fibrinolytic process (4–7).

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Author information

Authors and Affiliations

  1. The First Department of Medicine, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113, Japan

    Nobuo Aoki

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  1. Nobuo Aoki
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Editors and Affiliations

  1. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China

    Chung Yuan Liu

  2. University of California, San Diego, La Jolla, California, USA

    Shu Chien

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Aoki, N. (1990). Molecular Genetics of Alpha 2 Plasmin Inhibitor. In: Liu, C.Y., Chien, S. (eds) Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis. Advances in Experimental Medicine and Biology, vol 281. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3806-6_19

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  • DOI: https://doi.org/10.1007/978-1-4615-3806-6_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6697-3

  • Online ISBN: 978-1-4615-3806-6

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