Skip to main content
SpringerLink
Log in

Thrombin Inhibition by Synthetic Hirudin Peptides

  • Chapter
Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 281))

Abstract

Thrombin (EC 3.4.21.5) is a central, bioregulatory enzyme in thrombosis and hemostasis (1, 2). Thrombin activities are diverse and include fibrin clot formation (3) and stabilization (4), platelet and other cellular activation (5–7), and both positive and negative control of its own zymogen activation (8, 9). When compared to other serine proteinases of the coagulation and fibrinolytic systems, thrombin is unique in lacking the majority of its propiece (prothrombin fragment F 1.2) following zymogen activation (10, 11). Accordingly, the various specificities of thrombin must be accommodated solely within the enzyme moiety consisting of A and B chains.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. J. W. Fenton IIAnn. NYAcad. Sci., 485:5–15 (1986).

    Article  Google Scholar 

  2. J. W. Fenton IISemin. Thrombos. Hemostas., 12:200–208 (1986).

    Article  CAS  Google Scholar 

  3. B. Blomback,in: Plasma Proteins (B. Blomback, and L. A., Hanson, eds.) pp. 223–253, Wiley, New York (1979).

    Google Scholar 

  4. L. Lorand, and K. Konishi, Arch. Biochem. Biophys., 105:58–67 (1964).

    Article  PubMed  CAS  Google Scholar 

  5. D. M. Tollefsen, J. R. Feagler, and P. W. Majerus, J. Biol. Chem., 249:2646–2651 (1974).

    PubMed  CAS  Google Scholar 

  6. G. M. RodgersFASEB J., 2:116–123 (1988).

    PubMed  CAS  Google Scholar 

  7. R. W. ColmanBiochemistry, 8:1438–1445 (1969).

    Article  PubMed  CAS  Google Scholar 

  8. C. T. EsmonScience, 235:1348–1352 (1987).

    Article  PubMed  CAS  Google Scholar 

  9. C. T. Esmon, W. G. Owen, D. L. Duiguid, and C. M. Jackson, Biochim. Biophys. Acta, 310:289–294 (1973).

    Article  PubMed  CAS  Google Scholar 

  10. S. J. F. Degen, R. T. A. MacGillivray, and E. W. Davie, Biochemistry, 22:2087–2097 (1983).

    Article  PubMed  CAS  Google Scholar 

  11. M. J. Rabiet, A. Blashill, B. Furie, and B. C. Furie, J. Biol. Chem., 261:13210–13215 (1986).

    PubMed  CAS  Google Scholar 

  12. J.-Y. Chang, Eur. J. Biochem., 151:217–223 (1985).

    Article  PubMed  CAS  Google Scholar 

  13. J. W. Fenton IISemin. Thrombos. Hemostas., 15:265–268 (1989).

    Article  Google Scholar 

  14. J. W. Fenton II J. I. Witting, C. Pouliott, and J. Fareed, Ann. NY Acad. Sci., 556:158–165 (1989).

    Article  PubMed  CAS  Google Scholar 

  15. T.-L. Chang, R. D. Feinman, B. H. Landis, and J. W. Fenton IIBiochemistry, 18:113–119 (1979).

    Article  PubMed  CAS  Google Scholar 

  16. S. D. Lewis, L. Lorand, J. W. Fenton II, and J. A. Shafer, Biochemistry, 26:7597–7603 (1987).

    Article  PubMed  CAS  Google Scholar 

  17. J. Dodt, H. P. Muller, U. Seemuller, and J.-Y. Chang, FEBS Lett., 165:180–184 (1984).

    Article  CAS  Google Scholar 

  18. F. MarkwardtBiomed. Biochim. Acta, 44:1007–1013 (1985).

    PubMed  CAS  Google Scholar 

  19. J. W. Fenton II, B. H. Landis, D. A. Walz, D. H. Bing, R. D. Feinman, M. P. Zabinski, S. A. Sonder, L. J. Berliner, and J. S. Finlayson, in: The Chemistry and Physiology of Human Plasma Proteins (D. H. Bing, ed.) Pergamon Press, New York, pp. 151–183.

    Google Scholar 

  20. S. R. Stone, and J. HofsteengeBiochemistry, 25:4622–4628 (1986).

    Article  PubMed  CAS  Google Scholar 

  21. S. R. Stone, P. J. Braun, and J. Hofsteenge, Biochemistry, 26:4617–4624 (1987).

    Article  PubMed  CAS  Google Scholar 

  22. J.-Y. Chang, FEBS Lett., 164:307–313 (1983).

    Article  PubMed  CAS  Google Scholar 

  23. S. Bajusz, I. Fauszt, E. Barabas, N. Diosegi, and D. Bagdy,in: Peptides (U. Ragnarsson, ed.) Almqvist and Wiksell Int., Stockholm, pp. 473–476 (1984).

    Google Scholar 

  24. G. Noe, J. Hofsteenge, G. Rovelli, and S. R. Stone, J. Biol. Chem., 263:11729–11735 (1988).

    PubMed  CAS  Google Scholar 

  25. J. L. Krstenansky, T. J. Owen, M. T. Yates, and S. J. T. Mao, J. Med. Chem., 30:1688–1691 (1987).

    Article  PubMed  CAS  Google Scholar 

  26. D. Bagdy, E. Barabas, L. Graf, T. Ellebaek, and S. Magnusson, Methods Enzymol., 45:669–678 (1976).

    Article  PubMed  CAS  Google Scholar 

  27. J. Dodt, S. Kohler, and A. BaiciFEBS Lett., 229:87–90 (1988).

    Article  PubMed  CAS  Google Scholar 

  28. R. P. Harvey, E. Degryse, L. Stefani, F. Schamber, J. P. Cazenave, M. Courtney, P. Tolstoshev, and J. P. Lecocq, Proc. Natl. Acad. Sci. USA, 83:1084–1088 (1986).

    Article  PubMed  CAS  Google Scholar 

  29. G. Loison, A. Findeli, S. Bernard, M. Nguyen-Juilleret, M. Marquet, N. Riejl-Bellon, D. Carvallo, L. Guerra-Santos, S. W. Brown, M. Courtney, C. Roitsch, and Y. Lemoine, Biotechnology, 6:72–77 (1988).

    Article  CAS  Google Scholar 

  30. J. L. Krstenansky, and S. J. T. Mao, FEBS Lett., 211:10–16 (1987).

    Article  PubMed  CAS  Google Scholar 

  31. J. M. Maraganore, B. Chao, M. L. Joseph, J. Jablonski, and K. L. Ramachandran, J. Biol. Chem., 264:8692–8698 (1989).

    PubMed  CAS  Google Scholar 

  32. J. A. Jakubowsky, and J. M. MaraganoreBlood, 72:1213 (abtract) (1988).

    Google Scholar 

  33. J. A. Jakubowsky, and J. M. Maraganore, Blood, 75:399–406 (1990).

    Google Scholar 

  34. S. M. Prescott, A. R. Seeger, G A Zimmerman, T. M. MacIntyre, and J. M. Maraganore, J. Biol. Chem., in press (1990).

    Google Scholar 

  35. P. Bourdon, and J. M. Maraganore, Thromb. and Haemostas.,62:533 (abstract) (1989).

    Google Scholar 

  36. P. Bourdon, J. W. Fenton II, and J. M. Maraganore, Biochemistry, in press (1990).

    Google Scholar 

  37. W. Bode, I. Mayr, U. Baumann, R. Huber, S. R. Stone, and J. Hofsteenge, EMBO J., 8:3467–3475 (1989).

    PubMed  Google Scholar 

  38. B. Furie, D. H. Bing, R. J. Feldmann, D. J. Robison, J. P. Burnier, and B. C. Furie, J. Biol. Chem., 257:3875–3882 (1982).

    PubMed  CAS  Google Scholar 

  39. T. M. Palabrica, M. J. Aronovitz, J. M. Maraganore, and M. A. Konstam, Thrombos. and Hemostas., 62:434 (abstract) (1989).

    Google Scholar 

  40. Y. Cadroy, J. M. Maraganore, S. R. Hanson, and L. A. Harker, Thrombos. and Haemostas., 62:188 (abstract) (1989).

    Google Scholar 

  41. Y. Cadroy, J. M. Maraganore, S. R. Hanson, and L. A. Harker, Proc. Natl. Acad. Sci. USA, submitted (1989).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biogen, Inc., Cambridge, MA, USA

    John M. Maraganore

  2. Wadsworth Center for Laboratories and Research New York State Department of Health Departments of Physiology and Biochemistry, The Albany Medical College of Union University, Albany, NY, USA

    John W. Fenton II

Authors
  1. John M. Maraganore
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John W. Fenton II
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China

    Chung Yuan Liu

  2. University of California, San Diego, La Jolla, California, USA

    Shu Chien

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer Science+Business Media New York

About this chapter

Cite this chapter

Maraganore, J.M., Fenton, J.W. (1990). Thrombin Inhibition by Synthetic Hirudin Peptides. In: Liu, C.Y., Chien, S. (eds) Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis. Advances in Experimental Medicine and Biology, vol 281. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3806-6_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3806-6_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6697-3

  • Online ISBN: 978-1-4615-3806-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation