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Detection and Elimination of Blood-Borne Viruses Transmitted by Transfusion

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Medical Virology 10

Abstract

A decade-long epidemic of AIDS has continued to raise an unprecedented concern about the safety of our blood supply. Considering that nearly four million American patients receive the life-saving benefits of blood transfusion every year, we need to recognize several of the inherent biological complications incidental to receiving transfusions (Vyas, 1988). The underlying phenomena of allogenic stimulation and suppression of the transfusion recipient’s hemopoetic and immune systems facilitate graft-vs-host disease (Thaler et al. 1989; Vogelsang, 1990), as well as transmission of a variety of blood-borne viruses (BBVs) harbored by apparently healthy blood donors (Rawal et al. 1990a, b). The BBVs include hepatitis B viruses (HBV), hepatitis C viruses (HCV), hepatitis delta virus (HDV), human immunodeficiency virus (HIV-1/2), human T-cell leukemia virus (HTLV-I/II) and cytomegalovirus (CMV). Transfusion-transmitted BBVs cause a spectrum of multisystem diseases, including chronic hepatitis, liver cancer, AIDS, lymphoma-leukemia and myelopathy.

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Authors and Affiliations

  1. Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA

    Girish N. Vyas

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  1. Girish N. Vyas
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Editors and Affiliations

  1. Irvine Medical Center, University of California, Orange, California, USA

    Luis M. de la Maza  & Ellena M. Peterson  & 

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© 1991 Springer Science+Business Media New York

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Vyas, G.N. (1991). Detection and Elimination of Blood-Borne Viruses Transmitted by Transfusion. In: de la Maza, L.M., Peterson, E.M. (eds) Medical Virology 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3738-0_9

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  • DOI: https://doi.org/10.1007/978-1-4615-3738-0_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6664-5

  • Online ISBN: 978-1-4615-3738-0

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