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Genetic Variation at the APOA-I, C-III, A-IV Gene Complex: A Critical Review of the Associations Between the PSTI and SSTI RFLPS at this Locus with Lipid Disorders

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Book cover DNA Polymorphisms as Disease Markers

Part of the book series: NATO ASI Series ((NSSA,volume 214))

Abstract

Low levels of plasma high density lipoprotein (HDL) cholesterol constitute one of the major risk factor for coronary heart disease (CHD) in Western societies. The association of low HDL cholesterol levels with an increased risk of CHD was noted almost forty years ago and it has been supported by a large number of studies carried out primarily during the past 15 years 1–4. While the genetic factors affecting low density lipoprotein (LDL) levels are relatively well known 5,6, there is very little knowledge about the factors involved in the genetic control of plasma HDL.

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Author information

Authors and Affiliations

  1. Lipid Metabolism Laboratory. USDA Human Nutrition Research Center on Aging, Tufts University, Boston, USA

    Jose M. Ordovas, Fernando Civeira, Carmen Garces & Miguel Pocovi

  2. Department of Cellular and Molecular Biology, University of Zaragoza, Spain

    Jose M. Ordovas, Fernando Civeira, Carmen Garces & Miguel Pocovi

Authors
  1. Jose M. Ordovas
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  2. Fernando Civeira
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  3. Carmen Garces
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  4. Miguel Pocovi
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Editor information

Editors and Affiliations

  1. Department of Medicine, St. Bartholomew’s Hospital, West Smithfield, London, EC1A 7BE, UK

    D. J. Galton

  2. Zentrallaboratorien der Medizinische Einrichtungen, University of Munster, Germany

    G. Assmann (Director) (Director)

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Ordovas, J.M., Civeira, F., Garces, C., Pocovi, M. (1991). Genetic Variation at the APOA-I, C-III, A-IV Gene Complex: A Critical Review of the Associations Between the PSTI and SSTI RFLPS at this Locus with Lipid Disorders. In: Galton, D.J., Assmann, G. (eds) DNA Polymorphisms as Disease Markers. NATO ASI Series, vol 214. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3690-1_9

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  • DOI: https://doi.org/10.1007/978-1-4615-3690-1_9

  • Publisher Name: Springer, Boston, MA

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