Abstract
Retinoic Acid (RA) affects differentiation and morphogenesis in various developmental systems, including the vertebrate limb (Brickell and Tickle, 1989; Brookes, 1989), and acts by binding to nuclear RA receptors which are members of the steroid/thyroid hormone family of ligand-binding transcription factors (Green and Chambon, 1988; de The et al, 1990). Three closely-related RA receptors (RAR-alpha, RAR-beta and RAR-gamma), encoded by distinct genes and with distinct patterns of expression (Ruberte et al, 1990), have been identified in humans and mice, and a fourth RA receptor (hRXR-alpha) was discovered recently in humans (Mangelsdorf et al, 1990). Whilst still a member of the steroid/thyroid hormone receptor family, hRXR-alpha shares no significant homology with the RA-binding domain of RAR-alpha, RAR-beta or RAR-gamma and appears to represent an evolutionarily distinct RA response pathway (Mangelsdorf et al, 1990). We have isolated a cDNA clone encoding a chicken homologue of hRXR-alpha (cRXR) and have used this to examine the distribution of cRXR transcripts in chick embryos.
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© 1991 Springer Science+Business Media New York
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Rowe, A., Eager, N.S.C., Saville, M., Wolpert, L., Brickell, P.M. (1991). Expression Pattern of an RXR Nuclear Receptor Gene in the Chick Embryo. In: Hinchliffe, J.R., Hurle, J.M., Summerbell, D. (eds) Developmental Patterning of the Vertebrate Limb. NATO ASI Series, vol 205. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3310-8_15
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DOI: https://doi.org/10.1007/978-1-4615-3310-8_15
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