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A New Chemotherapeutic Agent: L-Asparaginase Entrapped in Red Blood Cells

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The Use of Resealed Erythrocytes as Carriers and Bioreactors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 326))

Abstract

The results of an investigation aimed at the prodution of a new therapeutic form of L-asparaginase loaded erythrocytes are presented.

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References

  1. F.I. Ataullakhanov, V.M. Vitvitsky, A.M. Zhabotinsky and A.V. Pichugin, Permeability of human erythrocytes to asparagine, Biokhimiya (Moscow) 50:1733(1985).

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  2. R. Riccardi, J.S. Holcenberg, D.L. Glaubiger, J.H. Wood and D.G. Poplack, L-asparaginase pharmacokinetics and asparagine levels in cerebrospinal fluid of Rhesus monkeys and humans, Cancer Res. 41:4554(1981).

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  3. J. De Loach and G. Ihler, A dialysis procedure for loading erythrocytes with enzyme and lipid, Biochim.Biophys. Acta 496:136(1977).

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  4. E.I. Sinauridze, A method to prepare drug-loaded erythrocytes, Author’s certificate of the USSR N 1469609 of December 1, 1988 for the statement N 4161064 declared on December 15, 1986.

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  5. V.A. Agranenko, F.I. Ataullakhanov, V.M. Vitvitsky, A.B. Kijatkin, A.M. Zhabotinsky, N.A. Markova and E.I. Sinauridze, A way to preserve drug-loaded erythrocytes prepared using dialysis method, Approval of the Institute of State Patent Expertise of the USSR of June 27, 1991 of the statement N 4856882 declared on August 24, 1990.

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Author information

Authors and Affiliations

  1. National Scientific Centre for Hematology, Moscow, Russia

    Elena I. Sinauridze, Victor M. Vitvitsky, Alexey V. Pichugin, Anatoly M. Zhabotinsky & Fazoil I. Ataullakhanov

Authors
  1. Elena I. Sinauridze
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  2. Victor M. Vitvitsky
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  3. Alexey V. Pichugin
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  4. Anatoly M. Zhabotinsky
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  5. Fazoil I. Ataullakhanov
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Editor information

Editors and Affiliations

  1. University of Urbino, Urbino, Italy

    Mauro Magnani

  2. Agricultural Research Service Food Animal Protection Research Laboratory, United States Department of Agriculture, College Station, Texas, USA

    John R. DeLoach

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© 1992 Springer Science+Business Media New York

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Sinauridze, E.I., Vitvitsky, V.M., Pichugin, A.V., Zhabotinsky, A.M., Ataullakhanov, F.I. (1992). A New Chemotherapeutic Agent: L-Asparaginase Entrapped in Red Blood Cells. In: Magnani, M., DeLoach, J.R. (eds) The Use of Resealed Erythrocytes as Carriers and Bioreactors. Advances in Experimental Medicine and Biology, vol 326. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3030-5_25

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  • DOI: https://doi.org/10.1007/978-1-4615-3030-5_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6321-7

  • Online ISBN: 978-1-4615-3030-5

  • eBook Packages: Springer Book Archive

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