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Inter-Relationships between Pterins and Cytokines Produced During Allogeneic Immune Reactions and Possible Use as Early Markers of Immune Activation

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Chemistry and Biology of Pteridines and Folates

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 338))

Abstract

The pterins neopterin and xanthopterin have been measured together with the cytokines IFN-γ, TNF-α and TNF-β in the supernatants of 20 allogeneic mixed lymphocyte reactions. We have calculated rank correlation coefficients between these analytes and the immune response. Our findings confirm that neopterin is a sensitive early marker of immune activation and show that another pterin, xanthopterin could be used likewise. Cytokine production was also proportional to immune activation but none could be used consistently as early markers of immune activation.

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Author information

Authors and Affiliations

  1. Department of Immunology, Charing Cross & Westminster Medical School, University of London, 369 Fulham Rd, London, SW10 9NH, UK

    J. J. Rippin & D. C. Henderson

Authors
  1. J. J. Rippin
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  2. D. C. Henderson
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Editor information

Editors and Affiliations

  1. Dept of Pharmacology College of Medicine, Universily of South Alabama, Mobile, AL, 36688, USA

    June E. Ayling

  2. Dept. of Biochemistry College of Medicine, University of South Alabama, Mobile, AL, 36688, USA

    M. Gopal Nair

  3. College of Medicine, Universily of South Alabama, Mobile, AL, 36688, USA

    Charles M. Baugh

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© 1993 Springer Science+Business Media New York

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Rippin, J.J., Henderson, D.C. (1993). Inter-Relationships between Pterins and Cytokines Produced During Allogeneic Immune Reactions and Possible Use as Early Markers of Immune Activation. In: Ayling, J.E., Nair, M.G., Baugh, C.M. (eds) Chemistry and Biology of Pteridines and Folates. Advances in Experimental Medicine and Biology, vol 338. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2960-6_48

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  • DOI: https://doi.org/10.1007/978-1-4615-2960-6_48

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6287-6

  • Online ISBN: 978-1-4615-2960-6

  • eBook Packages: Springer Book Archive

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