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Detergent-Insolubility During the Biosynthesis of Membrane Folate Receptor-2

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Chemistry and Biology of Pteridines and Folates

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 338))

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Abstract

Membrane folate recepter (MFR) type 2 is one of the two isoforms originally identified in human placenta 1. In the rough Endoplasmic Reticulum MFR-2 is provided with N-linked oligosaccharide chains and a glycosyl phosphatidylinositol (GPI) membrane-anchor, which has been shown to serve as a signal for the targeting of proteins to the apical plasma membrane domain in epithelial cells2. It has been suggested that GPI-linked proteins are sorted in the Golgi complex into microdomains enriched in glycolipids and cholesterol which leads to directional transport to the apical domain3,4,5. Recently, it has been shown that newly synthesized GPI-linked proteins have less lateral mobility when they arrive at the plasma membrane as compared to GPI-linked proteins that were allready present at the cell surface, again suggesting clustering of GPI-linked proteins at the plasma membrane6.

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Author information

Authors and Affiliations

  1. Dept. of Oncology, Medical Faculty, Free University, Amsterdam, The Netherlands

    Simon Rijnboutt, Engelien Bijleveld & Gerrit Jansen

  2. Dept. of Internal Medicine, The Dutch Cancer Institute, Amsterdam, The Netherlands

    Jan Schornagel

  3. Dept. of Cell Biology, Medical School, University of Utrecht, The Netherlands

    Ger Strous & George Posthuma

  4. Dept. of Biochemistry and Molecular Biology, Medical College of Ohio, Toledo, Ohio, USA

    Manohar Ratnam

Authors
  1. Simon Rijnboutt
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  2. Ger Strous
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  3. Engelien Bijleveld
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  4. George Posthuma
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  5. Manohar Ratnam
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  6. Jan Schornagel
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  7. Gerrit Jansen
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Editor information

Editors and Affiliations

  1. Dept of Pharmacology College of Medicine, Universily of South Alabama, Mobile, AL, 36688, USA

    June E. Ayling

  2. Dept. of Biochemistry College of Medicine, University of South Alabama, Mobile, AL, 36688, USA

    M. Gopal Nair

  3. College of Medicine, Universily of South Alabama, Mobile, AL, 36688, USA

    Charles M. Baugh

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© 1993 Springer Science+Business Media New York

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Rijnboutt, S. et al. (1993). Detergent-Insolubility During the Biosynthesis of Membrane Folate Receptor-2. In: Ayling, J.E., Nair, M.G., Baugh, C.M. (eds) Chemistry and Biology of Pteridines and Folates. Advances in Experimental Medicine and Biology, vol 338. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2960-6_159

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  • DOI: https://doi.org/10.1007/978-1-4615-2960-6_159

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6287-6

  • Online ISBN: 978-1-4615-2960-6

  • eBook Packages: Springer Book Archive

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