Abstract
Since the folate level decreases in plasma before its depletion, and this decrease in plasma is paralleled by a reduction in red blood cell folate, the levels in plasma are important clinical indicators that reflect folate status of the body of many mammalian species.1,2 Pregnancy is one of the important factor that is associated with negative folate balance, including progressively reduced serum and erythrocyte folate levels, and increased urinary folate excretion.1 N5-methyltetrahydrofolic acid (CH3-H4PteGlu) generally comprises most or all of the plasma folate in many mammalian species. Recently, however, tetrahydrofolic acid (H4PteGlu) was found to exist as the primary form of folate in the plasma of pigs,3 suggesting interspecies differences in folate metabolism.
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Natsuhori, M., Kokue, Ei., Shimoda, M. (1993). Influence of Gestation and Lactation on the Levels of Plasma Folates in Sows. In: Ayling, J.E., Nair, M.G., Baugh, C.M. (eds) Chemistry and Biology of Pteridines and Folates. Advances in Experimental Medicine and Biology, vol 338. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2960-6_152
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DOI: https://doi.org/10.1007/978-1-4615-2960-6_152
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