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On the importance of protein phosphorylation in cell cycle control

  • Chapter
Reversible Protein Phosphorylation in Cell Regulation

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 11))

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Abstract

This chapter is written as a contribution to a volume commemorating the work of Krebs and Fischer that led to award ing of the Nobel Prize in 1992. This award was made because of their fundamental discovery in the mid-1950s that protein phosphorylation was the underlying mechanism that accounted for the reversible modification of activity of glycogen phosphorylase in mammalian skeletal muscle. Although it could not be anticipated at the time that phosphorylation would turn out to be such a ubiquitous regulator of cellular functions, it is now evident that phosphorylation controls virtually every important reaction in cells and provides the basis for understanding how integrated cellular behavior is regulated by both extracellular signals and internal control mechanisms. This chapter relates the historical development in biochemical terms of protein phosphorylation as a regulator of the cell cycle in Xenopus oocytes and eggs. (Mol Cell Biochem 127/128: 267–281, 1993)

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  1. Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, Colorado, 80262, USA

    James L. Maller

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  1. Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, S7N 0W0

    R. L. Khandelwal

  2. Department of Medical Biochemistry, University of Calgary, Health Science Centre, 3330 Hospital Drive N.W., Calgary, Alberta, Canada, TZN 4N1

    J. H. Wang

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© 1993 Kluwer Academic Publishers

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Maller, J.L. (1993). On the importance of protein phosphorylation in cell cycle control. In: Khandelwal, R.L., Wang, J.H. (eds) Reversible Protein Phosphorylation in Cell Regulation. Developments in Molecular and Cellular Biochemistry, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2600-1_25

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  • DOI: https://doi.org/10.1007/978-1-4615-2600-1_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-2637-3

  • Online ISBN: 978-1-4615-2600-1

  • eBook Packages: Springer Book Archive

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