Abstract
Inosine-5’-monophosphate dehydrogenase (EC 1.1.1.205, IMPDH) is a branch point enzyme in the synthesis of adenine and guanine nucleotides and is the rate-limiting enzyme in the de novo synthesis of guanine nucleotides.1 This enzyme has an essential role in providing necessary precursors for DNA and RNA biosynthesis, a role that can be verified by the abrupt cessation of DNA synthesis when cells are treated with IMPDH inhibitors and by the circumvention of this effect with the addition of exogenous guanosine.2
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F.R. Collart, J. Osipiuk, J.D. Trent, and E. Huberman (unpublished information).
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Huberman, E., Glesne, D., Collart, F. (1995). Regulation and Role of Inosine-5’-Monophosphate Dehydrogenase in Cell Replication, Malignant Transformation, and Differentiation. In: Sahota, A., Taylor, M.W. (eds) Purine and Pyrimidine Metabolism in Man VIII. Advances in Experimental Medicine and Biology, vol 370. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2584-4_155
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DOI: https://doi.org/10.1007/978-1-4615-2584-4_155
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