Abstract
Urinary oxalate is supposedly derived from three sources: the diet (10–20%), ascorbate breakdown (40–50%) and endogenous metabolism (40–50%)1. Factors influencing oxalate excretion remain poorly defined. Endogenous metabolism, which appears to occur predominantly in the liver, is thought to involve amino acid catabolism1. Therefore, dietary protein as a source of amino acid may influence urinary oxalate excretion. However, studies with humans have not been conclusive. We have used a guinea pig model to further study the effects of dietary protein on urinary oxalate excretion. This animal model was chosen since the guinea pig, like humans, has a key biosynthetic enzyme, alanine-glyoxylate aminotransferase type I (AGT), located only in peroxisomes2. Guinea pigs were fed semi-purified diets containing 10, 20% or 40% of casein based protein. Urinary oxalate was monitored and hepatic AGT, glycolate oxidase (GO) and lactate dehydrogenase (LDH) levels were measured. Since glucagon is a known mediator of dietary protein metabolism, the effects of pharmacologic doses of this hormone on urinary oxalate excretion and hepatic enzyme levels were also examined.
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© 1994 Springer Science+Business Media New York
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Holmes, R.P., Hurst, C.H., Assimos, D.G. (1994). The Effect of Dietary Protein and Glucagon on the Urinary Excretion of Oxalate in the Guinea Pig. In: Ryall, R., Bais, R., Marshall, V.R., Rofe, A.M., Smith, L.H., Walker, V.R. (eds) Urolithiasis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2556-1_36
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DOI: https://doi.org/10.1007/978-1-4615-2556-1_36
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