Abstract
The active vitamin D, 1,25-dihydroxycholecalciferol (DHCC), plays an important role in the pathogenesis of calcium urolithiasis. Increased 1,25-DHCC levels are found in 30 – 80 % of hypercalciuric patients1-3. The underlying mechanisms, however, are not understood completely. In an experimental study we investigated whether cellular processes are important for the pathogenesis of vitamin D-induced nephrolithiasis and whether cytoprotective drugs as calcium antagonists can influence these processes.
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References
K-H Bichler, WL Strohmaier, M Schreiber, S Korn and I Gaiser, Hyperkalziurie und Vitamin D-Stoffwechsel. Fortschr UrolNephrol 22: 342 (1984).
KL Insogna, AE Broadus, BE Dreyer, AS Ellison and JM Gertner, Elevated production rate of 1,25-dihydroxy vitamin D in patients with absorptive hypercalciuria, J Clin Endocrinol Metab 61: 490 (1985).
FB Stapleton, CB Langman, J Bittle and LA Miller, Increased serum concentrations of 1,25 (OH)2 vitamin D in children with fasting hypercalciuria, J Pediatr 110: 234 (1987).
H Oßwald, W Steinbrecher, G Weinheimer, B Wagner, J Kleinschroth, J Hartenstein and G Satzinger, Antihypertensive activity of a novel calcium antagonist, Goe 5584-A, in rat models of hypertension, J Cardiovasc Pharmacol 12II, suppl.6: 154 (1988).
K-H Bichler, WL Strohmaier in: “Nephrocalcinosis, Calcium Antagonists and Kidney” Springer, Berlin (1988).
T Weinreich, J Merke, M Schonermark, H Reichel, M Diebold, GM Haensch and E Ritz, Actions of 1,25-dihydroxyvitamin D3 on human mesangial cells, Am J Kidney Dis 18: 359 (1991).
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© 1994 Springer Science+Business Media New York
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Strohmaier, W.L., Seeger, R.D., Oßwald, H., Bichler, KH. (1994). Protective Effects of Calcium Antagonists on Vitamin-Induced Nephrolithiasis. In: Ryall, R., Bais, R., Marshall, V.R., Rofe, A.M., Smith, L.H., Walker, V.R. (eds) Urolithiasis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2556-1_245
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DOI: https://doi.org/10.1007/978-1-4615-2556-1_245
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