Abstract
The possible significance of low molecular weight inhibitors (Mg, citrate and pyrophosphate) in the prevention of calcium oxalate urolithiasis has been emphasized1. Estimation of total 24 h excretion of urinary inhibitors in stone-formers (SF) will not reveal any circadian fluctuations. However, measurements of 3-hourly urine samples collected over a 24 h span should give a better picture of their circadian rhythmicity, which may help to expose any urinary biological abnormalities present therein. Therefore, the circadian rhythm of the 3 h excretion of Mg, citrate and pyrophosphate, and urinary inhibitory activity towards calcium oxalate monohydrate (COM) crystallization in SF and healthy subjects (N), were investigated.
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References
K Kohri, J Garside and NJ Blacklock, The role of magnesium in calcium oxalate urolithiasis, Brit J Urol 61: 107 (1988).
D Wangoo, SK Thind, GS Gupta and R Nath, Chronobiology of urinary citrate amongst stone-formers and healthy males from North-Western India, Urol Res 19: 203 (1991).
RCG Russel and A Hodgkinson, Urinary excretion of inorganic pyrophosphate by normal subjects and patients with renal calculus, Clin Sci 31: 51 (1986).
FL Coe, HC Margolis, LH Deutsch and AL Strauss, Urinary macromolecular crystal growth inhibitors in calcium nephrolithiasis, Mineral Electrolyte Metab 3: 268 (1980).
Y Touitou, C Touitou, G Charransol et al, Alterations in circadian rhythmicity in calcium oxalate renal stone formers. Int J Chronbiol 8: 175 (1983).
N Kinoshita, Diurnal variation in plasma oxalate concentration and oxalate clearance in calcium oxalate stone formers with special Reference to the effect of oxalate loading, Hinyakika Kiya 33: 1331 (1987).
MK Li, DK Shum and S Choi, Detection of crystallization in inhibitory activity of whole urine with a gel model, Urol Res 15: 75 (1987).
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© 1994 Springer Science+Business Media New York
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Wangoo, D., Rattan, V., Thind, S.K., Gupta, G.S., Nath, R. (1994). Circadian Rhythmometric Studies on the Low Molecular Weight Urinary Inhibitors of Calcium Oxalate Urolithiasis. In: Ryall, R., Bais, R., Marshall, V.R., Rofe, A.M., Smith, L.H., Walker, V.R. (eds) Urolithiasis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2556-1_139
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DOI: https://doi.org/10.1007/978-1-4615-2556-1_139
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