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Do Bacterial Membranes Contribute to Calcium Oxalate (Caox) Crystal Deposition?

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Urolithiasis 2

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Abstract

Clinical studies demonstrate the presence of bacteria in as many as one third of calcium oxalate/phosphate stones1. A role for such organisms has not been previously recognized. Bacteria may develop intracellular calcium phosphate crystals (hydroxyapatite) in unique clinical situations (e.g. dental tartar) and when inoculated into calcium phosphate enriched growth media in vitro 2. Previous work in our laboratory suggests that bacteria may form intracellular electron dense deposits containing calcium when inoculated in human urine3. Such bacteria demonstrate x-ray powder diffraction patterns consistent with hydroxyapatite3, 4. Additional in vitro studies suggest that bacteria may form microcolonies on tissue surfaces in urines that demonstrate increased levels of calcium5. The following study was designed to test the hypothesis that bacteria or bacterial membranes (mineralized and non-mineralized) may form a platform for calcium oxalate crystal deposition.

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References

  1. J Hugosson, L Grenabo, H Hedlon, S Petterson, and S Seeberg, Bacteriology of upper urinary tract stones, J Urol 143: 965 (1990).

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  2. JJ Vogel, The microbial model in the study of calcification, in: “Methods of Calcified Tissue Preparation”, GR Dickson, ed, Elsevier Science Publishers, Amsterdam (1984).

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Authors and Affiliations

  1. Department of Surgery, Division of Urology, University of Florida College of Medicine, Gainesville, FL, USA

    M. S. Cohen & R. J. Lobinske

  2. Department of Pathology, University of Florida College of Medicine, Gainesville, FL, USA

    S. R. Khan

Authors
  1. M. S. Cohen
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  2. R. J. Lobinske
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  3. S. R. Khan
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Editor information

Editors and Affiliations

  1. Flinders Medical Centre, South Australia, Australia

    Rosemary Ryall  & Villis R. Marshall  & 

  2. Institute of Medical and Veterinary Science, Adelaide, Australia

    Renze Bais  & Allan M. Rofe  & 

  3. Mayo Clinic, Rochester, Minnesota, USA

    Lynwood H. Smith

  4. University of British Columbia, Vancouver, British Columbia, Canada

    Valerie R. Walker

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© 1994 Springer Science+Business Media New York

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Cohen, M.S., Lobinske, R.J., Khan, S.R. (1994). Do Bacterial Membranes Contribute to Calcium Oxalate (Caox) Crystal Deposition?. In: Ryall, R., Bais, R., Marshall, V.R., Rofe, A.M., Smith, L.H., Walker, V.R. (eds) Urolithiasis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2556-1_122

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  • DOI: https://doi.org/10.1007/978-1-4615-2556-1_122

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6091-9

  • Online ISBN: 978-1-4615-2556-1

  • eBook Packages: Springer Book Archive

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