Abstract
Apoptosis is a universal form of “programmed” cell death that appears to have a key role in the development and regulation of the immune system1. Induction of the apoptotic pathway is a complex event, but in most instances requires an initial stimulus. Such a stimulus can include the removal of key growth factors, stimulation of immature T cells or inappropriate activation signals. Both activated and immature T lymphocytes appear to undergo apoptosis when stimulated through the T cell receptor, indicating that a combination of the stimulatory events and the state of maturation of the T cells is important in determining a cell’s outcome.
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© 1995 Springer Science+Business Media New York
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Woods, G.M., Gabrilovich, D.I., Elsley, W., English, N., Knight, S.C. (1995). Dendritic Cells, Apoptosis and Murine Retrovirus. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_111
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DOI: https://doi.org/10.1007/978-1-4615-1971-3_111
Publisher Name: Springer, Boston, MA
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