Abstract
Atherosclerosis is a complex, multisystem disease whose underlying molecular and cellular mechanisms are poorly understood. Recent insights into the etiology and pathogenesis of this disease suggest that atherosclerosis may be viewed as an inflammatory disease linked to an abnormality in oxidation-mediated signals in the vasculature. The purpose of this brief review is to extend this notion to the molecular level by viewing oxidation-mediated signals as physiological regulators of vascular gene expression that function through specific oxidation-reduction (redox)-sensitive signal transduction pathways and transcriptional regulatory networks. Redox-sensitive regulation of vascular gene expression, especially of genes involved in vascular inflammatory and growth responses, represents an intriguing paradigm for understanding atherogenesis as well as for the development of novel therapeutic treatment regimens, drug design and diagnostic assessment of disease state.
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Medford, R.M. (1995). Antioxidants and Endothelial Expression of Vcam-1: A Molecular Paradigm for Atherosclerosis. In: Gallo, L.L. (eds) Cardiovascular Disease. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1959-1_16
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DOI: https://doi.org/10.1007/978-1-4615-1959-1_16
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