Abstract
The removal of excess cholesterol from peripheral cells is the first step in reverse cholesterol transport and many studies demonstrated a net removal of cellular cholesterol in response to HDL3 1,2.This function has been suggested to account for the inverse correlation between coronary heart disease risk and plasma levels of HDL-cholesterol3. In addition to unspecific cholesterol desorption from the plasma membrane4, depletion of cholesterol may be achieved by binding of HDL apolipoproteins to specific surface receptors and subsequent induction of cholesterol transport from internal stores to the plasma membrane 5,6
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Schmitz, G., Rogler, G., Drobnik, W., Trümbach, B., Moellers, C., Lackner, K.J. (1995). The Defect in HDL3 Mediated Efflux of Newly Synthesized Cholesterol is Associated with Impaired Activation of Protein Kinase C in Tangier Fibroblasts. In: Gallo, L.L. (eds) Cardiovascular Disease. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1959-1_11
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DOI: https://doi.org/10.1007/978-1-4615-1959-1_11
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