Abstract
Gene therapy for cancer is on the horizon and gene prophylaxis is likely under specific circumstances. However, prevention, or at least a lowered risk of developing cancer is possible now. The knowledge to accomplish prevention is based primarily on laboratory research with experimental animals. The basic principles of carcinogenesis, nutrition, and intermediary metabolism do not differ in most cases between nonhuman animals and people. There is every reason to be certain that most of the facts established in laboratories are effective for the prevention of cancer in people.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Ashendel, C.L., and Boutwell, R.K., 1979, Prostaglandin E and F levels in mouse epidermis are increased by tumor-promoting phorbol esters, Biochem. Biophys. Res. Commun. 90:623.
Baumann, C.A., Jacobi, H., and Rusch, H.P., 1939, The effects of diet on experimental tumor production, Am. J. Hyg. 30:1.
Baumann, C.A., and Rusch, H.P., 1939, Effect of diet on tumors induced by ultraviolet light, Am. J. Cancer 35:213.
Belman, S., 1983, Onion and garlic oils inhibit tumor promotion, Carcinogenesis 4:1063.
Belman, S., Solomon, J., Segal, A., Block, E., and Barany, G., 1989, Inhibitors of soybean lipoxygenase and mouse skin tumor promotion by onion and garlic components, J. Biochem. Toxicol. 4:151.
Benson, A.M., Batzinger, R.P., Ou, S.-Y.L., Bueding, E., Cha, Y.-N., and Talalay, P., 1978, Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo[a] pyrene by dietary antioxidants. Cancer Res. 38:4486.
Bischoff, F., and Long, M.L., 1938, The influence of calories per se upon the growth of sarcoma 180, Am. J. Cancer 32:418.
Boissonneault, G.A., Elson, C.A., and Pariza, M.W., 1986, Net energy effects of dietary fat on chemically induced mammary carcinogenesis in F-344 rats, J. Natl. Cancer Inst. 76:335.
Bollag, W., 1971, Therapy of chemically induced skin tumors of mice with vitamin A palmitate and vitamin A acid [retinoic acid], Experimentia 27:90.
Bollag, W., 1972, Prophylaxis of chemically induced benign and malignant epithelial tumors by vitamin A acid (retinoic acid). Eur. J. Cancer 8:689.
Boutwell, R.K., 1964, Some biological aspects of skin carcinogenesis, Prog. Exptl. Tumor Res. 4:207.
Boutwell, R.K., Brush, M.K., and Rusch, H.P., 1948, Some physiological effects associated with chronic caloric restrictions. Am. J. Physiol. 154:517.
Boutwell, R.K., Brush, M.K., and Rusch, H.P., 1949, The influence of vitamins of the B-complex on the induction of epithelial tumors in mice, Cancer Res. 9:747.
Braden, L.M., and Carroll, K.K., 1986, Dietary polyunsaturated fat in relation to mammary carcinogenesis in rats, Lipids 21:285.
Cohen, S.M., Wittenberg, J.F., and Bryan, G.T., 1976, Effect of avitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N-[4-(nitro-2-furyl)-2-thiazolyl] formamide, Cancer Res. 36:2334.
Emerick, R.J., Zile, M, and DeLuca, H.F., 1967, Formation of retinoic acid from retinol in the rat, Biochem J. 102:606.
Engle, R.W., and Copeland, D.H., 1952. Protective action of stock diets against cancer-inducing action of 2-acetylaminofluorene in rats. Cancer Res. 12:211.
Gali, H.V., Perchellet, E.M., Klish, D.S., Johnson, S.M., and Perchellet, J.-P., 1992, Antitumor-promoting activities of hydrolyzablc tannins in mouse skin, Carcinogenesis 13:715.
Griffin, A.C., and Jacobs, M.M. 1977, Effects of selenium on azo dye hepatocarcinogenesis, Cancer Lett. 3:177.
Hartman, P.E., and Shankel, D.M., 1990, Antimutagens and anticarcinogenesis: a survey of putative interceptor molecules, Environmental Mol. Mutagenesis 15:145.
Hayashi, Y., Nagao, M., Sugimura, T., Takayama, S., Tomatis, L., Wattenberg, L.W., and Wogan, G.N., 1986. Diet, Nutrition and Cancer. Princess Takamatsu Symposium, vol. 16, Japan Societies Press, Tokyo.
Hecht, S.S., Morse, M.A., Shantu, A., Stoner, G.D., Jordan, K.G., Choi, C.-I., and Chung, F.-L., 1989, Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone and the effect of diet, Carcinogenesis 10:1901.
Huang, M.-T., Smart, R.C., Wong, C.-Q., and Conney, A.H., 1988, Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferrulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 48:5941.
IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, 1993, Some Naturally Occurring Substances: Food Items and Constituents. Heterocyclic Aromatic Amines, and Mycotoxins, vol. 56.
Ip, C., 1981, Prophylaxis of mammary neoplasia by selenium supplementation in the initiation and promotion phase of chemical carcinogenesis, Cancer Res. 41:4386.
Ip, C., 1987, Fat and essential fatty acid in mammary carcinogenesis, Am. J. Clin. Nutr. 45:218.
Ip, C., Chin, S.F., Scimeca, J.A., and Pariza, M.W., 1991, Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Res. 51:6118.
Ip, C., and Ganther, H.E., 1990. Activity of methylated forms of selenium in cancer prevention. Cancer Res. 50:1206.
Ip, C., and Ganther, H.E., 1992. Comparison of selenium and sulfur analogs in cancer prevention, Carcinogenesis 13:1167.
Jacobi, H.P., and Baumann, C.A., 1940. The effect of fat on tumor formation. Am. J. Cancer 39:338.
Jacobs, M.M., Jansson, B., and Griffin, A.C., 1977, Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol acetate induction of colon tumors, Cancer Lett. 2:133.
Klurfeld, D.M., Welch, C.B., Davis, M.J., and Kritchevsky, D., 1989, Determination of degree of energy restriction necessary to reduce mammary tumorigenesis in rats during the promotion phase, J. Nutr. 119:286.
Kritchevsky, D., and Klurfeld, D.M., 1987. Caloric effects in experimental mammary tumorigenesis. Am. J. Clin. Nutr. 45:236.
Kuroda, Y., Shankel, D.M., and Waters, M.D., 1990, “Antimutagenesis and Anticarcinogenesis, Mechanisms II” Basic Life Sciences, vol. 52, Plenum Press, New York and London.
Larsen, C.D., 1945, Effects of cystine and calorie restriction on the incidence of spontaneous pulmonary tumors in strain A mice, J. Natl. Cancer Inst. 6:31.
Lavik, P.S., and Baumann, C.A., 1941. Dietary fat and tumor formation, Cancer Res. 1:181.
Lavik, P.S., and Baumann, C.A., 1943. Further studies on the tumor promoting action of fat, Cancer Res. 3:749.
LePage, G.A., Potter, V.R., Busch, H., Heidelberger, C., and Hurlbert, R.B., 1952, Growth of carcinoma implants in fed and fasted rats. Cancer Res. 12:153.
Liu, J., Gilbert, K., Parker, H.M., Hashek, W.M., and Milner, J.A., 1991, Inhibition of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and DNA adducts by dietary selenite, Cancer Res. 51:4613.
McCay, C.M., Crowell, M.F., and Maynard, L.A., 1935, The effect of retarded growth upon the length of the life span and upon the ultimate body size, J. Nutr. 10:63.
McCay, C.M., Ellis, G.H., Barnes, L.L., Smith, C.A.H., and Spewling, G., 1939, Chemical and pathological changes in aging and after retarded growth, J. Nutr. 18:15.
Messina, M.J., Persky, V., Setchell, K.D.R., and Barnes, S., 1994, Soy intake and cancer risk: a review of in vitro and in vivo data, Nutrition and Cancer 21:113.
Miller, E.C., and Miller, J.A., 1979, Miletones in Chemical Carcinogenesis, Seminars in Oncology 6:445.
Miller, E.C., and Miller, J.A., 1979, Naturally occurring chemical carcinogens that may be present in food, in “Biochemistry of Nutrition IA,” A. Neuberger and T.H. Jakes, eds., University Park Press, Baltimore.
Miller, E.C., Miller, J.A., Hirono, I., Sugimura, T., and Takayama, S., 1979, Naturally Occurring Carcinogens-Mutagens and Modulators of Carcinogenesis, Japan Scientific Societies Press, Tokyo.
Milner, J.A., 1989, Mechanism for nutritional inhibition of cancer, in “Nutrition and Cancer Prevention, Investigating the Role of Micronutrients,” T.E. Moon and M.S. Micozzi, eds., Marcel Decker, New York.
Moon, R.C., McCormick, D.L., and Mehta, R.G., 1983, Inhibition of carcinogenesis by retinoids, Cancer Res. 43:2469.
Moreschi, C., 1909, Beziehungen zwischen emährung und tumorwachstum, Z. Immunitsforsh. 2:651.
Mottram, J.C., 1944, A developing factor for experimental blastogenesis, J. Path. Bact. 56:181.
Nelson, A.A., Fitzhugh, O.G., and Calvery, H.O., 1943, Liver tumors following cirrhosis caused by selenium in rats. Cancer Res. 3:230.
Pariza, M.W., and Felton, J.S., 1990. Mutagens and Carcinogens in the Diet, Wiley-Liss, New York.
Reddy, B.S., and Maeura, Y., 1984. Tumor promotion by dietary fats in azoxymethane-induced colon carcinogenesis in female F344 rats: influence of amount and source of dietary fat, J. Natl. Cancer Inst. 72:745.
Roebuck, B.D., Yager, J.D., Longnecker, D.S., and Wilpone, S.A., 1981, Promotion by unsaturated fat of azaserine-induced pancreatic carcinogenesis in the rat, Cancer Res. 41:3961.
Rous, P., 1914, The influence of diet on transplanted and spontaneous mouse tumors, J. Exptl. Med. 20:433.
Rowland, I.R., 1991. Nutrition, Toxicity and Cancer, CRC Press, Boca Raton, FL.
Rusch, H.P., Kline, B.E., and Baumann, C.A., 1945, The influence of caloric restriction and of dietary fat on tumor formation with ultraviolet radiation, Cancer Res. 5:431.
Saffiotti, U., Montesano, R., SellaKumar, A.R., and Borg, S.A., 1967, Experimental cancer of the lung. Inhibition by vitamin A of the induction of trachealbronchial metaplasia and squamous cell tumors, Cancer 20:857.
Saxton, J.A., Boon, M.C. and Furth, J., 1944, Observations on the inhibition of the development of spontaneous leukemia in mice by underfeeding, Cancer Res. 4:401.
Scott, M.L., 1973, The selenium dilemma, J. Nutr. 103:803.
Shamsuddin, A.M., Elsayed, A.M., and Ullah, A., 1988, Suppression of large intestinal cancer in F344 rats by inositol hexaphosphate, Carcinogenesis 9:577.
Silverstone, H., Solomon, R.D., and Tannenbaum, A., 1952, Relative influences of natural and semipurified diets on tumor formation in mice. Cancer Res. 12:750.
Sivertsen, I., and Hastings, W.H., 1938. A preliminary report on the influence of food and function on the incidence of mammary gland tumor in A stock albino mice, Minn. Med. 21:873.
Sparnins, V.L., Barany, G., and Wattenberg, L., 1988, Effects of organo-sulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione-S-transferase activity, Carcinogenesis 9:131.
Sparnins, V.L., and Wattenberg, L.W., 1981, Enhancement of glutathione S-transferase activity of the mouse forestomach by inhibitors of benzo[a]pyrene-induced neoplasia of this anatomic site, J. Natl. Cancer Inst. 66:769.
Takigawa, M., Verma, K., Simsiman, R.C., and Boutwell, R.K., 1983, Inhibition of mouse skin tumor promotion and of promoter-stimulated epidermal polyamine synthesis by α-difluoromethylornithine. Cancer Res. 43:3732.
Tannenbaum, A., 1940, The initiation and growth of tumors. I. Effects of underfeeding, Am. J. Cancer 38:335.
Tannenbaum, A., 1942, The genesis and growth of tumors. III. Effects of a high fat diet, Cancer Res. 2:468.
The Alpha-tocopherol, Beta-carotene Cancer Prevention Study Group, 1994, The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in male smokers. New Eng. J. Med. 330:1029.
Vanderhoek, J. Y., Makheja, A. R., and Bailey, J. M., 1980, Inhibition of fatty acid oxygenases by onion and garlic oils, Biochem. Pharmacol. 29:3169.
Verma, A.K., 1989, Inhibition of phorbol ester-induced ornithine decarboxylase gene transcription by retinoic acid: a possible mechanism of antitumor promoting action of retinoids, Prog. Clin. Biol. Res. 259:245.
Verma, A.K., Ashendel, C.L., and Boutwell, R.K., 1980, Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-0-tetradecanoylphorbol-13-acetate, Cancer Res. 40:308.
Verma, A.K., and Boutwell, R.K., 1977, Vitamin A acid (retinoic acid), a potent inhibitor of 12-0-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis, Cancer Res. 37:2197.
Verma, A.K., Rice, K.M., and Boutwell, R.K., 1977, Prostaglandins and skin tumor promotion: inhibition of tumor promoter-induced ornithine decarboxylase activity in epidermis by inhibitors of prostaglandin synthesis, Biochem. Biophys. Res. Commun. 79:1160.
Verma, A.K., Shapas, B.G., Rice, H.M., and Boutwell, R.K., 1979, Correlation of the inhibition by retinoids of tumor promoter-induced epidermal ornithine decarboxylase activity and of skin tumor promotion. Cancer Res. 39:419.
Visscher, M.B., Ball, Z.B., Barnes, R.H., and Sivertsen, I., 1942, The influence of caloric restriction upon the incidence of spontaneous mammary carcinoma in mice, Surgery 11:48.
Volk, M.J., Pugh, T.D., Moon, J.K., Frith, C.H., Daynes, R.A., Ershler, W.B., and Weindruch, R., 1994, Dietary restrictions from middle age attenuates age-associated lymphoma development and IL-6 deregulation in C57BL/6 mice. Cancer Res. 54:May 15 issue.
Wargovich, M.J., Woods, C., Eng, V.W.S., Stephens, L.C., and Gray, K., 1988, Chemoprevention of N-nitrosomethylbenzylamine-induced esophageal cancer in rats by the naturally occurring thioether, diallylsulfide. Cancer Res. 48:6872.
Watson, A.F., and Mellanby, E., 1930. Tar cancer in mice II: the condition of the skin when modified by external treatment or diet, as a factor influencing the cancerous reaction, Brit. J. Exptl. Path. 11:311.
Wattenberg, L.W., 1971. Studies of polycyclic hydrocarbon hydroxylases of the intestine possibly related to cancer. Effect of diet on benzpyrene hydroxylase activity, Cancer 28:99.
Wattenberg, L.W., 1977, Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzylisothiocyanate and related compounds, J. Natl. Cancer Inst. 58:395.
Wattenberg, L.W., 1987. Inhibitory effects of benzylisotheocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice, Carcinogenesis 8:1971.
Wattenberg, L.W., 1992a, Inhibition of carcinogenesis by minor dietary constituents. Cancer Res. (Suppl.) 52:2085s.
Wattenberg, L.W., 1992b. Chemoprevention of cancer by naturally occurring and synthetic compounds, in “Cancer Chemoprevention,” L. Wattenberg, M. Lipkin, C.W. Boone, and G.J. Kelloff, eds., CRC Press, Inc., Boca Raton, FL.
Wattenberg, L.W., Coccia, J.B., and Lam, L.K.T., 1980, Inhibitory effects of phenolic compounds on benzo[a]pyrene-induced neoplasia, Cancer Res. 40:2820.
Weindruch, R., Albanes, D., and Kritchevsky, D., 1991, The role of calories and caloric restriction in cancer, Hematol./Oncol. Clinics No. America 5:79.
Weindruch, R., and Walford, R.L., 1982. Dietary restriction in mice beginning at 1 year of age: effects on life span and spontaneous cancer incidence, Science 215:1415.
Welsch, C.W., House, J.L., Herr, B.L., Eliasberg, S.S., and Welsch, M.A., 1990, Enhancement of mammary carcinogenesis by high levels of dietary fat: a phenomenon dependent on ad libitum feeding, J. Natl. Cancer Inst. 82:1615.
Willett, W.C., 1994, Diet and health: what should we eat?, Science 264:532.
Wilt, S., Pereira, M., and Couri, D., 1979, Selenium effect on initiation and promotion of tumors by benzo[a]pyrene and 12-0-tetradecanoylphorbol, Proc. Am. Assoc. Cancer Res. 20:21.
Wolbach, S.B., and Howe, P.R., 1925, Tissue changes following deprivation of fat soluble A vitamin, J. Exptl. Med. XLII:753.
Zhang, Y., Kensler, T.W., Cho, C-G., Posner, G.H., and Talalay, P., 1994, Proc. Natl. Acad. Sci. 91:3147.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Boutwell, R.K. (1995). Nutrition and Carcinogenesis: Historical Highlights and Future Prospects. In: Longenecker, J.B., Kritchevsky, D., Drezner, M.K. (eds) Nutrition and Biotechnology in Heart Disease and Cancer. Advances in Experimental Medicine and Biology, vol 369. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1957-7_11
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1957-7_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5804-6
Online ISBN: 978-1-4615-1957-7
eBook Packages: Springer Book Archive