Abstract
Epithelial cells (EC) resident to cutaneous tissues are important producers of various immunostimulatory, proinflammatory and inhibitory cytokines1,2 Locally produced cytokines in epithelial tissues mediate events relevant to growth, differentiation and function of surrounding cells. Based on their capacity to induce various cell adhesion molecules, as well as “secondary” cytokines,3 they play an important role in intercellular communications. Since immunocompetence of epithelial tissues may be influenced by maturation and aging,4-6 the aim of the present study was to obtain more information on the age-related changes of production of relevant cytokines. To examine this, we investigated age-related expression of TNF, IL-1 and IL-6 by comparing secretory potential of EC normally resident to skin of fetal, neonatal and adult rats.
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References
S. Stosic-Grujicic and M. L. Lukic, Immunology 75: 293 (1992).
C. F. Bigler, D. A. Norris, W. L. Weston, and W. P. Arrend, J. Invest. Dermatol 98: 38 (1992).
T. S. Kupper, J. Clin.. Invest. 86: 1783 (1990).
D. N. Sauder, B. M. Stanulis-Praeger, and B. A. Gilchrest, Arch. Dermatol Res. 280: 71 (1988).
D. V. Belsito, S. P. Epstein, J. M. Schultz, R. L. Bear, and G. J. Thorbecke, J. Immunol 143: 1530 (1989).
C. D. Dijkstra, E. P. Van Rees, and E. A. Döpp, in:“Histophysiology of the Immune System”, S. Fossum, and B. Rolstad, (eds.), p. 731, Plenum Press, New York and London (1988).
S. Stosic-Grujicic, D. J. Lalosevic, and M. L. Lukic, Int. J. Immunopharmac. 9: 577 (1987).
S. F. Orencole and C. A. Dinarello, Cytokine 1: 14 (1989).
L. A. Aarden, E. R. De Groot, L. O. Schaap, and P. M. Landsdorp, Eur. J. Immunol 17: 1411 (1987).
S. K. Burchett, W. M. Weaver, J. A. Westall, A. Larsen, S. Kronheim, and C. B. Wilson, J. Immunol 140: 3473 (1988).
S. Stosick-Grujicic, V. Stankovic, and M. L. Lukic, in:“Lymphatic Tissue and In vivo Immune Responses”, S. Ezine, S. Berrih-Akinin, and B. Imhof, (eds.), p. 321, Marcel Dekker Inc., NY (1991).
J. C. Ansel, T. A. Luger, D. Lowry, P. Perry, D. R. Roop, and J. D. Mounts, J. Immunol 140: 2274 (1988).
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Stosic-Grujicic, S.S., Lukic, M.L. (1995). The Production of TNF, IL-1 And IL-6 in Cutaneous Tissues During Maturation and Aging. In: Mestecky, J., Russell, M.W., Jackson, S., Michalek, S.M., Tlaskalová-Hogenová, H., Šterzl, J. (eds) Advances in Mucosal Immunology. Advances in Experimental Medicine and Biology, vol 371. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1941-6_86
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DOI: https://doi.org/10.1007/978-1-4615-1941-6_86
Publisher Name: Springer, Boston, MA
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