Abstract
It has been recognized since the work done by Nielsen and Smith (8) that hypoxia and hypercapnia interact multiplicatively in their effects on breathing. While this interaction has been convincingly demonstrated to occur at the level of the peripheral chemoreceptors in man (4,7) the possibility that there is some degree of central interaction as well can not be excluded (3,4).
Affiliated with the Faculties of Kinesiology and Medicine at the University of Western Ontario and The Lawson Research Institute at the St. Joseph’s Health Centre.
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St. Croix, C.M., Cunningham, D.A., Paterson, D.H. (1995). Central-Peripheral Ventilatory Chemoreflex Interaction in Humans. In: Semple, S.J.G., Adams, L., Whipp, B.J. (eds) Modeling and Control of Ventilation. Advances in Experimental Medicine and Biology, vol 393. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1933-1_66
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