Abstract
We investigated the effects of the following drugs on the eye-cup electroretinogram in albino rabbits: low-molecular-weight heparin to treat inflammation, colchicine to prevent postoperative cellular proliferation in the vitreous cavity and interferon ß for antiviral treatment. The a- and b-waves and the oscillatory potentials were unchanged during perfusion with 5 and 20 IU/ml low-molecular-weight heparin, 25 and 50 µg/ml colchicine or 5,000 and 10,000 IU/ml interferon ß. Potential clinical intravitreal use of low-molecular-weight heparin and interferon ß was suggested, respectively, for prophylaxis of postoperative intraocular fibrin reactions and proliferative vitreoretinopathy, and to treat viral retinitis.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
M. Lemor, S. de Bustros, and B. M. Glaser, Low-dose colchicine inhibits astrocyte, fibroblast, and retinal pigment epithelial cell migration and proliferation, Arch. Ophthalmol 104: 1223 (1986).
M. Lemor, J. H. Jeo, and B. M. Glaser, Oral colchicine for the treatment of experimental traction retinal detachment, Arch. Ophthalmol. 104: 1226 (1986).
N. Ishida, Strategies for antiviral chemotherapy, Atarashii Ganka 9:173 (1992).
Y. Ohashi, T. Sasabe, T. Nishida, and R. Manabe, Natural killer cells kill human retinoblastma cells, Jpn. J. Ophthalmol. 28: 370 (1984).
T. Yokoyama, O. Yoshie, H. Aso, T. Ebina, N. Ishida, and K. Mizuno, Role of natural killer cells in intraocular melanoma metastasis, Invest. Ophthalmol. Vis.Sci. 27: 516 (1986).
S. Hamano, M. Kinukawa, H. Komatsu, S. Ikeda, and N. Sakuragawa, Effects of low molecular weight heparin (FR-860) on coagulative and fibrinolytic activities, Folia Pharmacol. Japon 94: 243 (1989).
M. S. Blumenkranz, M. K. Hartzer, and D. Iverson, An overview of potential applications of heparin in vitreoretinal surgery, Retina 12: S71 (1992).
R. N. Johnson, and G. Blankenship, A prospective, randomized, clinical trial of heparin therapy for postoperative intraocular fibrin, Ophthalmology 95: 312 (1988).
D. A. Iverson, H. Katsura, M. K. Hartzer, and M. S. Blumenkranz, Inhibition of intraocular fibrin formation following infusion of low-molecular-weight heparin during vitrectomy, Arch.Ophthalmol. 109: 405 (1991).
H. Kondo, H. Hayashi, and K. Oshima, Fibrin prophylaxis with low molecular weight heparin during intraocular surgery, Jpn. J. Ophthalmic Surg. 6: 597 (1993).
J. N. P. Kirkpatrick, A. D. Dick, and J. V. Forrester, Clinical experience with interferon alfa-2a for exudative age-related macular degeneration, Br. J. Ophthalmol. 77: 766 (1993).
S. Vegh, J. Vernot, G. A. Peyman, and R. Fiscella, Toxicity of intravitreal interferon, OphthalmicSurg. 17: 103 (1986).
S. K. Dharma, G. A. Peyman, J. Vernot, and R. Fiscella, Toxicity of intravitreally administered alpha-interferon, Ophthalmic Surg. 18: 51 (1987).
M. A. Karaçorlu, G. A. Peyman, S. Cruz, K. F. Soike, Lack of toxicity of intravitreally administered interferon alpha-2a, Ophthalmic Surg. 23: 833 (1992).
K. Ohki, G. A. Peyman, A. Candel, and R. Fiscella, Toxicity of intravitreal interferon in combination with acyclovir after lensectomy and vitrectomy, Folia Ophthalmol. Jpn. 38: 158 (1987).
D. H. Berman and G. M. Gombos, Proliferative vitreoretinopathy: Does oral low-dose colchicine have an inhibitory effect? A controlled study in humans, Ophthalmic Surg. 20: 268 (1989).
J. O. Karlsson, H. A. Hansson, and J. Sjöstrand, Effect of colchicine on axonal transport and morphology of retinal ganglion cells, Z. Zeilforsch. 115: 265 (1971).
O. L. Vaccarezza, E. Pasqualini, and J. P. Saavedra, Retinal alterations induced by intravitreous colchicine, Virchows Arch.Abt.B Zellpath. 12: 159 (1973).
C. Davidson, W. R. Green, and V. G. Wong, Retinal atrophy induced by intravitreous colchicine,Invest. Ophthalmol. Vis.Sci. 24: 301 (1983).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Yamashita, Y., Mochizuki, K., Sakai, H., Torisaki, M., Tanabe, J. (1995). Retinal Tolerance of Intravitreal Low-Molecular-Weight Heparin, Colchicine or Interferon ß Determined by Eye-Cup ERG in Albino Rabbits. In: Weisse, I., Hockwin, O., Green, K., Tripathi, R.C. (eds) Ocular Toxicology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1887-7_9
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1887-7_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5769-8
Online ISBN: 978-1-4615-1887-7
eBook Packages: Springer Book Archive