Abstract
Studies in adult animals with acute respiratory failure have demonstrated that intratracheal administration of perflubron (perfluorooctyl-bromide, Alliance Pharmaceutical Corp., San Diego, CA) improves PaO2 values [1]. However, data on perflubron administration in healthy animals showed a decrease in PaO2 values [2]. It is speculated that this decrease could originate from an elevation of surface tension in healthy animals, combined with the mechanical effect of perflubron moving in the lungs during ventilation. The aim of this study was to assess the effect of vaporized perflubron on blood gases and lung mechanics in healthy animals.
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References
Tűtűcnű AS, Lachmann B, Faithfull NS, Erdmann W. Dose dependent improvement of gas exchange by intratracheal Perflubron (perfluorooctylbromide) instillation in adult animals with acute respiratory failure. Adv Exp Med Biol 1992; 317:397–400.
Fuhrman BP, Parczan PR, DeFrancisis M. Perfluorocarbon-associated gas exchange. Crit Care Med 1991; 19:712
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© 1994 Springer Science+Business Media New York
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Houmes, R.J., Lachmann, B., Faithfull, N.S., Erdmann, W. (1994). Influence of Intratracheal Perflubron Vapor on Lung Mechanics and Blood Gases. In: Hogan, M.C., Mathieu-Costello, O., Poole, D.C., Wagner, P.D. (eds) Oxygen Transport to Tissue XVI. Advances in Experimental Medicine and Biology, vol 361. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1875-4_82
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DOI: https://doi.org/10.1007/978-1-4615-1875-4_82
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