Abstract
Numerous animal studies have shown that normovolemic anemia does not decrease wound tensile strength until hematocrit falls below 17%. Although anemia does decrease arterial oxygen content, decreased blood viscosity may allow increased tissue perfusion and thus normal tissue oxygenation. Prior studies of anemia and healing have not evaluated oxygen delivery to the wound. Since the rate of collagen deposition in wounds is proportional to local oxygen tension, the lack of a detrimental effect of anemia on wound healing may be due to increased tissue perfusion. In the present study, subcutaneous tissue oxygen (PsqO2) was measured in normovolemic anemic rabbits to evaluate the effect of anemia on tissue perfusion.
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© 1994 Springer Science+Business Media New York
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Hopf, H.W., Swanson, D., Hunt, T.K. (1994). Moderate Anemia Does Not Decrease Subcutaneous Tissue Oxygen Tension in Rabbits. In: Hogan, M.C., Mathieu-Costello, O., Poole, D.C., Wagner, P.D. (eds) Oxygen Transport to Tissue XVI. Advances in Experimental Medicine and Biology, vol 361. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1875-4_60
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DOI: https://doi.org/10.1007/978-1-4615-1875-4_60
Publisher Name: Springer, Boston, MA
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