Abstract
The classical (alkaline) Bohr effect is the shift of the oxygen (O2) hemoglobin (Hb) binding curve of whole blood by carbon dioxide (CO2). The effect has two components, which may be assessed separately: (1) Direct interaction of CO2 with amino groups of hemoglobin (CO2-Bohr effect) and (2) indirect influence via change of pH (proton Bohr effect). The second can be quantitatively characterized by the so called proton Bohr factor (PBF): ә logP50/ ә pH (P50: O2 partial pressure at half saturation of hemoglobin). Generally PBF depends on all parameters affecting O2-Hb binding, e.g. pH, PCO2, temperature.
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Barnikol, W.K.R. (1994). The Proton Bohr Factor of Native and Crosslinker Treated Hemoglobins - Its Possible Significance for the Efficacy of Hemoglobin Based Artificial Oxygen Carriers. In: Hogan, M.C., Mathieu-Costello, O., Poole, D.C., Wagner, P.D. (eds) Oxygen Transport to Tissue XVI. Advances in Experimental Medicine and Biology, vol 361. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1875-4_56
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