Abstract
A number of previous studies have attempted to manipulate tumor oxygenation and blood flow for the purpose of enhancing either chemo-or radiotherapy. Increased blood flow and oxygen delivery have commonly been used to improve both radioresponse and the delivery of conventional chemotherapeutic agents (Fenton and Sutherland, 1992;
Rice et al.,1986). However, decreased oxygen delivery can also be beneficial. If tumor oxygen levels are reduced, the effectiveness of either bioreductive agents or hypoxic radiosensitizers can be enhanced (Bibby et al.,1989; Quinn et al.,1992). To better understand the underlying physiological mechanisms and thereby optimize therapeutic manipulation, a primary goal is to define the basic interrelationships among tumor vascular structure, blood flow, oxygen delivery, and radioresponse.
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Fenton, B.M., Siemann, D.W. (1994). Investigations of Perfusion-Limited Hypoxia and Oxygenation in the KHT Sarcoma. In: Hogan, M.C., Mathieu-Costello, O., Poole, D.C., Wagner, P.D. (eds) Oxygen Transport to Tissue XVI. Advances in Experimental Medicine and Biology, vol 361. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1875-4_115
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DOI: https://doi.org/10.1007/978-1-4615-1875-4_115
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