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Circadian Rhythms in Affective Disorders

  • Chapter
Circadian Clocks

Part of the book series: Handbook of Behavioral Neurobiology ((HBNE,volume 12))

Abstract

The affective or mood disorders are among the most common psychiatric conditions. They cause considerable morbidity and mortality, and therefore have received a great deal of research attention. For reasons which will be described below, researchers with an interest in circadian rhythms have been among those working to understand the pathophysiology and etiology of mood disorders. In this chapter, we will review their work, along with the conceptual and methodological issues that have complicated it.

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References

  • Achermann, P., & Borbüly, A. A. (1990). Simulation of human sleep: Ultradian dynamics of electro- YTHMS IN encephalographic slow-wave activity. Journal of Biological Rhythms, 5, 141–157.

    Article  PubMed  CAS  Google Scholar 

  • American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders (4th ed.). SORDERS Washington, DC: Author.

    Google Scholar 

  • Aschoff, J. (1983). Disorders of the circadian system as discussed in psychiatric research. In T. Wehr & F. Goodwin (Eds.), Circadian rhythms in psychiatry (pp. 33–39). Pacific Grove, CA: Boxwood Press.

    Google Scholar 

  • Avery, D., Dahl, K, Savage, M., Brenglemann, G., Larson, L., Bitiello, M., & Prinz, P. (1990). The temperature rhythm is phase-delayed in winter depression (Abstract). Biological Psychiatry, 27, 99A.

    Google Scholar 

  • Benca, R. M., Obermeyer, W. H., Thisted, R. A., & Gillin, J. C. (1992). Sleep and psychiatric disorders: A meta-analysis. Archives of General Psychiatry, 49, 651–668.

    Article  PubMed  CAS  Google Scholar 

  • Borbüly, A. A. (1982). A two process model for sleep regulation. Human Neurobiology, 1, 200–205.

    Google Scholar 

  • Borbüly, A. A., & Wirz-Justice, A. (1982). Sleep, sleep deprivation and depression: A hypothesis derived from a model of sleep regulation. Human Neurobiology, 1, 205–210.

    Google Scholar 

  • Checkley, S. (1989). The relationship between biological rhythms and the affective disorders. In J. Arendt, D. S. Minors, & J. Waterhouse (Eds.), Biological rhythms in clinical practice. London, Butterworth.

    Google Scholar 

  • Czeisler, C. A., Kronauer, R. E., Mooney, J. J., Anderson, J. L., & Allan, J. S. (1987). Biologic rhythm disorders, depression and phototherapy. Psychiatric Clincs of North America, 10, 687–709.

    CAS  Google Scholar 

  • Dahl, K., Avery, D. H., Lewy, A.J., Savage, M. V., Brenglemann, G. L., Larsen, L. H., Vitiello, M. V., & Prinz, P. N. (1993). Dim light melatonin onset and circadian temperature during a constant routine in hypersomnic winter depression. Acta Psychiatrica Scandinavica, 88, 60–66.

    Article  PubMed  CAS  Google Scholar 

  • Daimon, K., Yamada, N., Tsujimoto, T., & Takahashi, S. (1992). Circadian rhythm abnormalities of deep body temperature in depressive disorders. Journal of Affective Disorders, 26, 191–198.

    Article  PubMed  CAS  Google Scholar 

  • Dew, M. A., Reynolds, C. F., Buysse, D. J., Houck, P. R., Hoch, C. C., Monk, T. H., & Kupfer, D. J. (1996). Electroencephalographic sleep profiles during depression. Archives of General Psychiatry, 53,148–156.

    Article  PubMed  CAS  Google Scholar 

  • Dirlich, G., Kammerloher, A., Schulz, H., Lund, R., Doerr, P., & von Zerssen, D. (1981). Temporal coordination of rest-activity cycle, body temperature, urinary free cortisol and mood in a patient with 48-hour unipolar-depressive cycles in clinical and time-cue-free environments. Biological Psychiatry, 16, 163–179.

    PubMed  CAS  Google Scholar 

  • Ehlers, C. L., & Kupfer, D. J. (1987). Hypothalamic peptide modulation of EEG sleep in depression: A further application of the S-process hypothesis. Biological Psychiatry, 22, 513–517.

    Article  PubMed  CAS  Google Scholar 

  • Ehlers, C. L., Frank, E., & Kupfer, D. J. (1988). Social zeitgebers and biological rhythms: A unified approach to understanding the etiology of depression. Archives of General Psychiatry, 45, 948–952.

    Article  PubMed  CAS  Google Scholar 

  • Ehlers, C. L., Haystad, J. W., & Kupfer, D. J. (1996). Estimation of the time course of slow-wave sleep over the night in depressed patients: Effects of clomipramine and clinical response. Biological Psychiatry, 39, 171–181.

    Article  PubMed  CAS  Google Scholar 

  • Feldman-Naim, S., Turner, E. H., & Leibenluft, E. (1996). Circadian variation in the direction of mood switches in patients with rapid-cycling bipolar disorder. Poster presented at the 149th Annual Meeting of the American Psychiatric Association, New York.

    Google Scholar 

  • Frank, E., Shear, M. K., Essex, M. J., Leibenluft, E., & Monk, T. H. (1995). Routines, rhythms, and affective states: The relationship of lifestyle regularity to mood and anxiety disorders. Paper presented at the 34th Annual Meeting of the American College of Neuropsychopharmacology, San Juan, Puerto Rico.

    Google Scholar 

  • Georgi, F. (1947). Psychophysische korrelationen: III. Psychiatrische probleme im licte der rhythmusforschung. Schweizerische Medizinische Wochenschrift, 49, 1276–1280.

    Google Scholar 

  • Giles, D. E., Roffwarg, H. P., & Rush, A.J. (1987). REM latency concordance in depressed family members. Biological Psychiatry, 22, 910–914.

    Article  PubMed  CAS  Google Scholar 

  • Giles, D. E., Biggs, M. M., Rush, A. J., & Roffwarg, H. P. (1988). Risk factors in families of unipolar depression: I. Psychiatric illness and reduced REM latency. Journal of Affective Disorders, 14, 51–59.

    Article  PubMed  CAS  Google Scholar 

  • Giles, D. E., Kupfer, D. J., Roffwarg, H. P., Rush, A. J., Biggs, M. M., & Etzel, B. A. (1989). Polysom nographic parameters in first-degree relatives of unipolar probands. Psychiatry Research, 27,127–136.

    Article  PubMed  CAS  Google Scholar 

  • Goetze, U., & Tolle, R. (1987). Circadian rhythms of free urinary cortisol, temperature, and heart rate in endogenous depressives and under antidepressant therapy. Neuropsychobiology, 18, 175–184.

    Article  PubMed  CAS  Google Scholar 

  • Goodwin, F. K, & Jamison, K. R. (1990). Manic-depressive illness. Oxford: Oxford University Press.

    Google Scholar 

  • Gresham, S. C., Agnew, H. W., & Williams, R. L. (1965). The sleep of depressed patients: An EEG and eye movement study. Archives of General Psychiatry, 13, 503–507.

    Article  Google Scholar 

  • Halberg, F. (1968). Physiologic considerations underlying rhythmometry with special reference to emotional illness. In J. de Ajuriaguerra (Ed.), Cycles biologiques et psychiatrie (pp. 73–126). Paris: Masson.

    Google Scholar 

  • Haug, H.J., & Wirz-Justice, A. (1993). Diurnal variation of mood in depression: Important or irrelevant? Biological Psychiatry, 34, 201–203.

    Article  PubMed  CAS  Google Scholar 

  • Healy, D., & Waterhouse, J. M. (1990). The circadian system and affective disorders: Clocks or rhythms? Chronobiology International, 2 5–10.

    Article  Google Scholar 

  • Healy, D., & Waterhouse, J. M. (1995). The circadian system and the therapeutics of the affective disorders. Pharmacology and Therapeutics, 65, 241–263.

    Article  PubMed  CAS  Google Scholar 

  • Illnerova, H., & Vanecek, J. (1982). Two-oscillator structure of the pacemaker controlling the circadian rhythm of N-acetyltransferase in the rat pineal gland. Journal of Comparative Physiology, 145, 539–548.

    Article  CAS  Google Scholar 

  • Kessler, R. C., McGonagle, K. A., Zhao, S., Nelson, C. B., Hughes, M., Eshleman, S., Wittchen, H.-U., & Kendler, K. S. (1994). Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Archives of General Psychiatry, 51, 8–19.

    Article  PubMed  CAS  Google Scholar 

  • Kramlinger, K. G., & Post, R. M. (1996). Ultra-rapid and ultradian cycling in bipolar affective illness. British Journal of Psychiatry, 168, 314–323.

    Article  PubMed  CAS  Google Scholar 

  • Kripke, D. F., Mellaney, D. J., Atkinson, M., & Wolf, S. R. (1978). Circadian rhythm disorders in manic-depressives. Biological Psychiatry, 13, 335–351.

    PubMed  CAS  Google Scholar 

  • Kukopulos, A., Reginaldi, D., Laddomada, G., Floris, G., Serra, G., & Tondo, L. (1980). Course of the manic-depressive cycle and changes caused by treatments. Pharmacopsychiatry, 13, 156–157.

    CAS  Google Scholar 

  • Kupfer, D. J., & Foster, G. (1972). Interval between onset of sleep and rapid-eye-movement sleep as an indicator of depression. Lancet, 2, 684–686.

    Article  PubMed  CAS  Google Scholar 

  • Kupfer, D. J., Weiss, B. L., Foster, E G., Detre, T. P., Delgado, J., & McPartland, R. (1974). Psychomotor activity in affective states. Archives of General Psychiatry, 132, 928–931.

    Google Scholar 

  • Kupfer, D. J., Frank, E., Grochocincki, V. J., Gregor, M., & McEachran, A. B. (1988). EEG sleep profiles in recurrent depression: A longitudinal investigation. Archives of General Psychiatry, 45, 678–681.

    Article  PubMed  CAS  Google Scholar 

  • Lam, R. W., Berkowitz, A. L., Berga, S. L., Clark, C. M., Kripke, D. F., & Gillin, J. C. (1990). Melatonin suppression in bipolar and unipolar mood disorders. Psychiatry Research, 33, 129–134.

    Article  PubMed  CAS  Google Scholar 

  • Leibenluft, E., Schwartz, P. J., Turner, E. H., Rosenthal, N. E., & Wehr, T. A. (1993). State-dependent changes in pineal and thyroid axis function in patients with rapid-cycling bipolar disorder. Poster presented at the 32nd Annual Meeting of the American College of Neuropsychopharmacology, Honolulu, Hawaii.

    Google Scholar 

  • Leibenluft, E., Turner, E. H., Feldman-Naim, S., Schwartz, P. J., Wehr, T. A., & Rosenthal, N. E. (1995). Light therapy in patients with rapid cycling bipolar disorder: Preliminary results. Psychopharmacology Bulletin, 31, 705–710.

    PubMed  CAS  Google Scholar 

  • Lewy, A. J., Wehr, T. A., Goodwin, E K., Newsome, D. A., & Rosenthal, N. E. (1980). Light suppresses melatonin secretion in humans. Science, 210, 1267–1269.

    Article  PubMed  CAS  Google Scholar 

  • Lewy, A. J., Wehr, T. A., Goodwin, F. K., Newsome, D. A., & Rosenthal, N. E. (1981). Manic-depressive patients may be supersensitive to light. Lancet, 1, 383–384.

    Article  PubMed  CAS  Google Scholar 

  • Lewy, A. J., Sack, D. A., & Singer, C. M. (1984). Assessment and treatment of chronobiologic disorders using plasma melatonin levels and bright light exposure: The clock-gate model and the phase response curve. Psychopharmacology Bulletin, 20, 561–565.

    PubMed  CAS  Google Scholar 

  • Linkowski, P., Mendlewicz, J., Leclercq, R., Brasseur, M., Hubain, P., Golstein, J., Copinschi, G., & Van Canter, E. (1985). The 24-hour profile of adrenocorticotropin and cortisol in major depressive illness. Journal of Clinical Endocrinology and Metabolism, 61, 429–438.

    Article  PubMed  CAS  Google Scholar 

  • Linkowski, P., Mendlewicz, J., Kerhofs, M., Leclercq, R., Golstein, J., Brasseur, M., & Copinschi, G. (1987). 24-hour profile of adrenocorticotropin, cortisol, and growth hormone in major depressive illness: Effect of antidepressant treatment. Journal of Clinical Endocrinology and Metabolism, 65, 141–152.

    Article  PubMed  CAS  Google Scholar 

  • Linkowski, P., Van Onderbergen, A., Kerkhofs, M., Bosson, D., Mendlewicz, J., & Van Cauter, E. (1993). A twin study of the 24-hour cortisol profile: Evidence for genetic control of the human circadian clock. American Journal of Physiology, 264, E173–E181.

    PubMed  CAS  Google Scholar 

  • Mrosovsky, N., Reebs, S. G., Honrado, G. I., & Salmon, P. A. (1989). Behavioral entrainment of circadian rhythms. Experientia, 45, 696–702.

    Article  PubMed  CAS  Google Scholar 

  • Papousek, M. (1975). Chronobiologische aspekte der zyklothymie. Fortschritte der Neurologie Psychiatrie, 43, 381–440.

    CAS  Google Scholar 

  • Parry, B. L., Berga, S. L., Kripke, D. F., Klauber, M. R., Laughlin, G. A., Yen, S. S. C., & Gillin, J. C. (1990). Altered waveform of plasma nocturnal melatonin secretion in premenstrual depression. Archives of General Psychiatry, 47, 1139–1146.

    Article  PubMed  CAS  Google Scholar 

  • Parry, B. L., Hauger, R., Lin, E., LeVeau, B., Mostofi, N., Clopton, P. L., & Gillin, J. C. (1994). Neuroendocrine effects of light therapy in late luteal phase dysphoric disorder. Biological Psychiatry, 36, 356–364.

    Article  PubMed  CAS  Google Scholar 

  • Reinink, E., Bouhuys, N., Wirz-Justice, A., & van den Hoofdakker, R. (1990). Prediction of the antidepressant response to total sleep deprivation by diurnal variation of mood. Psychiatry Research, 32,113–124.

    Article  PubMed  CAS  Google Scholar 

  • Rosenthal, N. E., Sack, D. A., Gillin, J. C., Lewy, A. J., Goodwin, E K, Davenport, Y., Mueller, P. S., Newsome, D. A., & Wehr, T. A. (1984). Seasonal affective disorder: A description of the syndrome and preliminary findings with light therapy. Archives of General Psychiatry, 41, 72–80.

    Article  PubMed  CAS  Google Scholar 

  • Rosenthal, N. E., Levendosky, A. A., Skwerer, R. G., Joseph Vanderpool, J. R., Kelly, K. A., Hardin, T., Kasper, S., DellaBella, P., & Wehr, T. A. (1990). Effects of light treatment on core body temperature in seasonal affective disorder. Biological Psychiatry, 27, 39–50.

    Article  PubMed  CAS  Google Scholar 

  • Rubin, R. T., Heist, E. K, McGeoy, S. S., Hanada, K., & Lesser, I. M. (1992). Neuroendocrine aspects of primary endogenous depression. Archives of General Psychiatry, 49, 558–567.

    Article  PubMed  CAS  Google Scholar 

  • Rush, A. J., Erman, M. K, Giles, D. E., Schlesser, M. A., Carpenter, G., Vasavada, N., & Roffwarg, H. P. (1986). Polysomnographic findings in recently drug-free and clinically remitted depressed patients. Archives of General Psychiatry, 43, 878–884.

    Article  PubMed  CAS  Google Scholar 

  • Sack, D. A., Nurnberger, J., Rosenthal, N. E., & Wehr, T. A. (1985). Potentiation of antidepressant medica-tions by phase-advance of the sleep-wake cycle. American Journal of Psychiatry, 142, 606–608.

    PubMed  CAS  Google Scholar 

  • Sack, D. A., Rosenthal, N. E., Duncan, W. C., Mendelson, W. B., & Wehr, T. A. (1988). Early versus late partial sleep deprivation therapy of depression. Acta Psychiatrica Scandinavica, 77, 219–224.

    Article  PubMed  CAS  Google Scholar 

  • Sack, R. L., Lewy, A. J., & White, D. M. (1990). Morning versus evening light treatment for winter depression: Evidence that the therapeutic effects of light are mediated by circadian phase shifting. Archives of General Psychiatry, 47, 343–351.

    Article  PubMed  CAS  Google Scholar 

  • Schmidt, P.J., Nieman, L. K, Grover, G. N., Muller, K. L., Merriam, G. R., & Rubinow, D. R. (1991). Lack of effect of induced menses on symptoms in women with premenstrual syndrome. New England Journal of Medicine, 324, 1174–1179.

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, P. J., Brown, C., Wehr, T. A., & Rosenthal, N. E. (1996). Winter-seasonal affective disorder: A follow-up study of the first 59 patients of the National Institute of Mental Health seasonal studies program. American Journal of Psychiatry, 153, 1028–1036.

    PubMed  CAS  Google Scholar 

  • Seifritz, E., Muller, M. J., Trachsel, L., Lauer, C. J., Hemmeter, U., Hatzinger, M., Moore, P., & HolsboerTrachsler, E. (1996). Revisiting the Ehlers and Kupfer hypothesis: The growth hormone cortisol secretion ratio during sleep is correlated with electroencephalographic slow wave activity in normal volunteers. Biological Psychiatry, 39, 139–142.

    Article  PubMed  CAS  Google Scholar 

  • Shanahan, T. L., & Czeisler, C. A. (1991). Light exposure induces equivalent phase shifts of the endogenous circadian rhythms of circulating plasma melatonin and core body temperature in men. Journal of Clinical Endocrinology and Metabolism, 73, 227–235.

    Article  PubMed  CAS  Google Scholar 

  • Souetre, E., Salvati, E., Belugou, J. L., Pringuey, D., Candito, M., Krebs, B., Ardisson, J. L., & Darcourt, G. (1989). Circadian rhythms in depression and recovery: Evidence for blunted amplitude as the main chronobiological abnormality. Psychiatry Research, 28, 262–278.

    Article  Google Scholar 

  • Souetre, E., Wehr, T. A., & Rosenthal, N. E. (Unpublished). Biological clocks, depression and environment.

    Google Scholar 

  • Thalen, B. E., Kjellman, F., Morkrid, L., & Wetterberg, L. (1995). Melatonin in light treatment of patients with seasonal and nonseasonal depression. Acta Psychiatrica Scandinavica, 92, 274–284.

    Article  PubMed  CAS  Google Scholar 

  • Thompson, C., Franey, C., Arendt, J., & Checkley, S. A. (1988). A comparison of melatonin secretion in depressed patients and normal subjects. British Journal of Psychiatry, 152, 260–265.

    Article  PubMed  CAS  Google Scholar 

  • Tsujimoto, T., Yamada, N., Shimoda, K, Hanada, K, & Takahashi, S. (1990). Circadian rhythms in depression. Part II: Circadian rhythms in inpatients with various mental disorders. Journal of Affective Disorders, 18, 199–210.

    Article  PubMed  CAS  Google Scholar 

  • Vitaterna, M. H., King, D. P., Chang, A. M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. E, Pinto, L. H., Turek, E W., & Takahashi, J. S. (1994). Mutagenesis and mapping of mouse gene, Clock, essential for circadian behavior. Science, 264, 719–725.

    Article  PubMed  CAS  Google Scholar 

  • Vollmann, J., & Berger, M. (1993). Sleep deprivation with consecutive sleep-phase advance therapy in patients with major depression: A pilot study. Biological Psychiatry, 33, 54–57.

    Article  PubMed  CAS  Google Scholar 

  • Wehr, T. A. (1990a). Effects of sleep and wakefulness in depression and mania. In J. Montplaisir & R. Godbout (Eds.), Sleep and biological rhythms (pp. 42–86). Oxford: Oxford University Press.

    Google Scholar 

  • Wehr, T. A. (1990b). Reply to Healy D and Waterhouse JM: The circadian system and affective disorders: Clocks or rhythms? Chronobiology International, 7, 11–14.

    Article  Google Scholar 

  • Wehr, T. A., & Goodwin, F. K (1983). Biological rhythms in manic-depressive illness. In T. A. Wehr & F. K. Goodwin (Eds.), Circadian rhythms in psychiatry (pp. 129–184). Pacific Grove, CA: Boxwood Press.

    Google Scholar 

  • Wehr, T. A., & Wirz-Justice, A. (1980). Internal coincidence model for sleep deprivation and depression. Sleep, 26–33.

    Google Scholar 

  • Wehr, T. A., & Wirz-Justice, A. (1982). Circadian rhythm mechanisms in affective illness and in antidepressant drug action. Pharmacopsychiatry, 15, 31–39.

    Article  CAS  Google Scholar 

  • Wehr, T. A., Wirz-Justice, A., Goodwin, F. K, Duncan, W. C., & Gillin, J. C. (1979). Phase advance of the circadian sleep-wake cycle as an antidepressant. Science, 206, 710–713.

    Article  PubMed  CAS  Google Scholar 

  • Wehr, T. A., Muscettola, G., & Goodwin, E K (1980). Urinary 3-methoxy-4-hydroxy-phenylglycol circadian rhythms: Early timing (phase-advance) in manic depressives compared with normal subjects. Archives of General Psychiatry, 37, 257–263.

    Article  PubMed  CAS  Google Scholar 

  • Wehr, T. A., Goodwin, F. K, Wirz Justice, A., Breitmaier, J., & Craig, C. (1982). 48 hour sleep-wake cycle in manic-depressive illness: Naturalistic observations and sleep deprivation experiments. Archives of General Psychiatry, 39, 559–565.

    Article  PubMed  CAS  Google Scholar 

  • Wehr, T. A., Sack, D. A., Duncan, W. C., Mendelson, W. B., Rosenthal, N. E., Gillin, J. C., & Goodwin, F. K. (1985). Sleep and circadian rhythms in affective patients isolated from external time cues. Psychiatry Research, 15, 327–339.

    Article  PubMed  CAS  Google Scholar 

  • Wehr, T A., Sack, D. A., & Rosenthal, N. E. (1987a). Sleep reduction as a final common pathway in the genesis of mania. American Journal of Psychiatry, 144, 201–204.

    CAS  Google Scholar 

  • Wehr, T. A., Sack, D. A., & Rosenthal, N. E. (1987b). Seasonal affective disorder with summer depression and winter hypomania. American Journal of Psychiatry, 144, 1403–1411.

    CAS  Google Scholar 

  • Wehr, T A., Moul, D. E., Barbato, G., Giesen, H. A., Seidel, J. A., Barker, C., & Bender, C. (1993). Conservation of photoperiod-responsive mechanisms in humans. American Journal of Physiology, 265, R846—R857.

    PubMed  Google Scholar 

  • Wehr, T A., Giesen, H. A., Moul, D. E., Turner, E. H., & Schwartz, P. J. (1995). Suppression of human responses to seasonal changes in day-length by modern artificial lighting. American Journal of Physiology, 269, R173—R178.

    PubMed  Google Scholar 

  • Wirz-Justice, A. (1995). Biological rhythms in mood disorders. In F. E. Bloom & D. J. Kupfer (Eds.), Psychpharmacology: The fourth generation of progress (pp. 999–1016). New York: Raven Press.

    Google Scholar 

  • Wirz-Justice, A., Gravy, P., Krauchi, K, Gisin, B., Jochum, A., Arendt, J., Fisch, H. U., & Buddeberg, C. (1993). Light therapy in seasonal affective disorder is independent of time of day or circadian phase. Archives of General Psychiatry, 50, 929–937.

    Article  PubMed  CAS  Google Scholar 

  • Wolff, E. A., Putnam, F. W., & Post, R. M. (1985). Motor activity in affective illness: The relationship of amplitude and temporal distribution to changes in the affective state. Archives of General Psychiatry, 42, 288–294.

    Article  PubMed  Google Scholar 

  • Wu, J., & Bunney, W. (1990). The biological basis of an antidepressant response to sleep deprivation and relapse: Review and hypothesis. American Journal of Psychiatry, 147, 14–21.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Pediatrics and Developmental Neuropsychology Branch, National Institute of Mental Health, Bethesda, 20892-1255, Maryland

    Ellen Leibenluft

  2. Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, 15213, Pennsylvania

    Ellen Frank

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  1. Ellen Leibenluft
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  1. Northwestern University, Evanston, Illinois, USA

    Joseph S. Takahashi , Fred W. Turek  & Robert Y. Moore ,  & 

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Leibenluft, E., Frank, E. (2001). Circadian Rhythms in Affective Disorders. In: Takahashi, J.S., Turek, F.W., Moore, R.Y. (eds) Circadian Clocks. Handbook of Behavioral Neurobiology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1201-1_24

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  • DOI: https://doi.org/10.1007/978-1-4615-1201-1_24

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