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Mammalian Clock Genetics

  • Chapter
Circadian Clocks

Part of the book series: Handbook of Behavioral Neurobiology ((HBNE,volume 12))

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Abstract

Very early in the modern history of biological rhythm research, Erwin Bünning demonstrated that the circadian period was under genetic control (Bünning, 1935). The experiments not only verified the biological (endogenous) nature of rhythm generation, but also demonstrated the innate determination of circadian periodicity. At the start of a new millennium, the 65 years of research into clock genetics until recently had brought out only a rudimentary understanding of the direct role of genes in this process. Nonetheless, with the discovery of timeless in Drosophila, which has provided new insight into the activity and attributes of clock genes (see Chapter 14), the cloning of Clock in the mouse (King et al., 1997b; Vitaterna et al., 1994), and the identification of per homologues in the mammalian suprachiasmatic nucleus (SCN) (Sun et al., 1997; Tei et al., 1997), the field is poised for a significant assault on the genetic mechanisms of rhythm generation.

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Authors and Affiliations

  1. Department of Psychology, University of Toronto, M5S 3G3, Toronto, Canada

    Martin R. Ralph

  2. Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, 60208

    Martha Hotz Vitaterna

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  1. Northwestern University, Evanston, Illinois, USA

    Joseph S. Takahashi , Fred W. Turek  & Robert Y. Moore ,  & 

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Ralph, M.R., Vitaterna, M.H. (2001). Mammalian Clock Genetics. In: Takahashi, J.S., Turek, F.W., Moore, R.Y. (eds) Circadian Clocks. Handbook of Behavioral Neurobiology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1201-1_17

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