Abstract
Sjögren’s syndrome is an insidious and currently incurable autoimmune disorder occurring primarily in women, and associated with an extensive lymphocyte accumulation in the lacrimal gland, an immune-mediated destruction and/or dysfunction of acinar and ductal epithelial cells, a precipitous decrease in tear secretion and severe dry eye.1,2 Recently, we discovered that androgen administration to the female MRL/Mp-lpr/lpr (MRL/lpr) and NZB/NZW F1 mouse models of Sjögren’s syndrome causes a dramatic suppression of the inflammation in, and a significant increase in the functional activity of, lacrimal glands.3 However, the precise mechanism(s) underlying this hormone action is unknown.
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© 2002 Kluwer Academic/Plenum Publishers
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Bijlsma, W.R., Tonino, B.A.R., Richards, S.M., Liu, M., Sullivan, B.D., Sullivan, D.A. (2002). Androgen Influence on Lymphocyte Gene Expression. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_19
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_19
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