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Immunogenetics of Autoimmune Exocrinopathy in the Nod Mouse: More Than Meets the Eye

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 506))

Abstract

Sjögren’s syndrome is defined as a chronic inflammatory autoimmune disorder primarily affecting the lacrimal and salivary exocrine glands. However, the disorder has also been associated with numerous extraglandular manifestations affecting such diverse tissues as the cardiovascular, central nervous, and renal systems.1 Diagnostic criteria include oral and/or ocular dryness, focal lymphocytic infiltrates in the exocrine tissues, and the presence of autoantibodies in patient sera, particularly against the nuclear factors SSA/Ro and SS-B/La. Due to inconsistencies in the various diagnostic scales, evaluation of disease prevalence worldwide is difficult and complicated further by the chronic and inconsistent nature of the symptoms in patients. 1.2

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Author information

Authors and Affiliations

  1. Departments of ‘Oral Biology, USA

    M. G. Humphreys-Beher, J. Brayer, S. Cha, H. Nagashima & S. Diggs

  2. Pathology University of Florida, Gainesville, Florida, USA

    A. B. Peck

Authors
  1. M. G. Humphreys-Beher
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  2. J. Brayer
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  3. S. Cha
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  4. H. Nagashima
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  5. S. Diggs
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  6. A. B. Peck
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Editor information

Editors and Affiliations

  1. Schepens Eye Research Institute, Boston, Massachusetts, USA

    David A. Sullivan , Darlene A. Dartt  & Rose M. Sullivan ,  & 

  2. Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  3. Allergan, Inc., Irvine, California, USA

    Michael E. Stern

  4. Tokyo Dental College, Chiba, Japan

    Kazuo Tsubota

  5. Ichikawa General Hospital, Chiba, Japan

    Kazuo Tsubota

  6. University of New Orleans, New Orleans, Louisiana, USA

    B. Britt Bromberg

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© 2002 Kluwer Academic/Plenum Publishers

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Humphreys-Beher, M.G., Brayer, J., Cha, S., Nagashima, H., Diggs, S., Peck, A.B. (2002). Immunogenetics of Autoimmune Exocrinopathy in the Nod Mouse: More Than Meets the Eye. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_141

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  • DOI: https://doi.org/10.1007/978-1-4615-0717-8_141

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5208-2

  • Online ISBN: 978-1-4615-0717-8

  • eBook Packages: Springer Book Archive

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