Abstract
The mammalian carotid body (CB) is an oxygen addicted chemoreceptor organ, which consists of type I glomus, cells; the seat of oxygen sensing. There are two consensus hypotheses regarding the CB hypoxia signaling pathway; (a) non-respiratory/ plasma membrane and (b) respiratory/ metabolic.
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References
S. Lahiri, C. Rozanov, A. Roy, B. Storey, and D.G. Buerk, Regulation of oxygen sensing in peripheral arterial chemoreceptor, Int. J. Biochem.Cell Biol. 33, 755–774 (2001).
C.N. Wyatt, C. Wright, D. Bee, and C. Peers, 02-sensitive K+ currents in carotid body chemoreceptor cells from normoxic and chronically hypoxic rats and their roles in hypoxic chemotransduction., Proc Natl Acad Sci 92, 295–299 (1995).
L. Pang, and C. Eyzaguirre, Different effects of hypoxia on the membrane potential and input resistance of isolated and clustered carotid body glomus cells., Brain Res. 575, 167–173 (1992).
M.R. Duchen, and T.J. Biscoe, Relative mitochondrial membrane potential and [Ca2+]I in type I cells isolated from the rabbit carotid body, J Physiol. 450, 33–61 (1992).
S.S. Krylov, and S.V. Anichcov, The effects of metabolic inhibitors on carotid chemoreceptors, in Arterial Chemoreceptors,edited by R.W. Torrance (Blackwell, 1968), pp 103–109.
E. Mulligan, and S. Lahiri, Dependence of carotid chemoreceptor stimulation by metabolic agents on Pao2 and Paco2, J. Appl. Physiol. 50, 884–891 (1981).
A. Mokashi, D. Ray, F. Botre, M. Katayama, S. Osanai, and S.Lahir, Effects of hypoxia on intracellular pH of glomus cells cultured from rat and cat carotid bodies, JAppl Physiol. 78, 1875–1881 (1995).
H.J. Apell, and B. Bersch, Oxonol VI as an optical indicator for membrane potentials in lipid vesicles. Biochem BiophysActa, 903, 480–494 (1987).
T. Brauner, D.F. Hulser, and R.J. Strasser, Comparative measurements of membrane potentials with microelectrodes and voltage-sensitive dyes, Biochem BiophysActa. 771, 208–216 (1984).
A.B. A1-mehdi, H. Shuman, and A.B. Fisher, Oxidant generation with K’- induced depolarization in the isolated perfused lung, Free Radical Biol & Med. 23, 47–56 (1997).
C.F. Mohr, and C. Fewtrell, IgE receptor-mediated depolarization of rat basophilic leukemia cells measured with the fluorescent probe bis-oxonol J Immunol. 138 1564 - 570 (1987).
M. Reers, S.T. Smiley, C. Mottola-Hartshorn, A. Chen, M. Lin, and L.B. Chen, Mitochondrial membrane potential monitored by JC-1 dye, Methods in Enzymol., 260, 406–417 (1995).
J. Urena, R. Fernandez-Chacon, A.R. Benot, G. Alvarez de Toledo, and J. Lopez-Barreo, Hypoxia induces voltage dependent Ca2* entry and quantal dopamine secretion in carotid body glomus cells, Proc. Natl. Acad. Sci. 91, 10208–10211 (1994).
D.G. Buerk, S. Osanai, A. Mokashi, and S. Lahiri, Dopamine, sensory discharge, and stimulus interaction with CO2 and 02in cat carotid body, J. Appl. Physiol. 85, 1719–1726 (1998).
K.J. Buckler, A novel oxygen-sensitive potassium current in rat carotid body type I cells, J. Physiol. 498, 649–662 (1997).
D.F. Donnelly, IC currents of glomus cells and chemosensory functions of carotid body, Respir. Physiol. 115, 151–160 (1999).
N. Fujimura, E. Tanaka, S. Yamamoto, M. Shigemori, and H. Higashi, Contribution of ATP-sensitive potassium channels to hypoxic hyperpolarization in rat hippocampal CAl neurons in vitro, J. Neurophysiol. 77, 378–385 (1997).
G. Erdemi, Y.Z. Xu, and K. Knnjevic, Potassium conductance causing hyperpolarization of CAl hippocampal neurons during hypoxia, J. Neurophysiol. 80, 2378–2390 (1998).
C. Peers, and J. O’Donnell, Potassium currents recorded in type I carotid body cells from the neonatal rat and their modulation by chemoexcitatory agents, Brain Res. 572, 259–266 (1990).
C. Peers, Hypoxic suppression of K’ currents in type I carotid body cells: selective effect of Cat+-activated K* current, Neurosci. Lett. 119, 253–256 (1990).
D.M. McDonald, and R.A. Mitchell, The innervation of glomus cells, ganglion cells and blood vessels in the rat carotid body: a quantitative ultrastructural analysis, J. Neurocytol. 4, 177–230 (1975).
M.T. Perez-Garcia, A. Obeso, J.R. Lopez-Lopez, B. Herreros, and C. Gonzalez, Characterization of cultured chemoreceptor cells dissociated from adult rabbit carotid body, Am. J. Physiol. 263, C1152–C1159 (1992).
A. Roy, C. Rozanov, D.G. Buerk, A. Mokashi, and S. Lahiri, Suppression of glomus cell K. conductance by 4-aminopyridine is not related to [Ca21i, dopamine release and chemosensory discharge from carotid body, Brain Res. 785, 228–235 (1998).
K.J. Buckler, and R.D. Vaughan-Jones, Effects of mitochondrial uncouplers on intracellular calcium, pH and membrane potential in rat carotid body type I cells, J. Physiol. 513, 819–833 (1998).
A. Rocher, A. Obeso, C. Gonzalez, and B. Herreros, ionic mechanisms for the transduction of acidic stimuli in rabbit carotid body glomus cells, J. Physiol. 433, 533–548 (1991).
S. Lahiri, D.G. Buerk, D. Chugh, S. Osanai, A. Mokashi, Reciprocal photolabile 02 consumption and chemoreceptor excitation by carbon monoxide in the cat carotid body: evidence for cytochrome a3 as the primary 02 sensor, Brain Res. 684, 194–200 (1995).
A. Mokashi, A. Roy, C. Rozanov, S. Osanai, B.T. Storey, S. Lahiri, High Pco does not alter pHI, but raises [Ca2+]I in cultured rat carotid body glomus cells in the absence and presence of CdC12. Brain Res. 803, 194–197 (1998).
D.G. Buerk, D.K. Chugh, S. Osanai, A. Mokashi, S. Lahiri, Dopamine increases in cat carotid body during excitation by carbon monoxide: Implications for a chromophore theory of chemoreception., J Autonom New Sys. 67, 130–136 (1997).
AV. Nowicky, and M.R. Duchen, Changes in [Ca2+]1 and membrane currents during impaired mitochondria) metabolism in dissociated rat hippocampal neurons, J Physiol. 507, 131–145 (1998).
R. Rizzuto, P. Pinton, W. Carrington, F.S. Fay, K.E. Fogarty, L.M. Lifshitz, R.A. Tuft, and T. Pozzan, Close contacts with the endoplasmic reticulum as determinants of mitochondria) Ca2+ responses, Science, 280, 1763–1766 (1998).
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Roy, A., Al-mehdi, A.B., Mokashi, A., Lahiri, S. (2003). Importance of Glomus Cell Plasma Membrane and Mitochondrial Membrane Potentials During Acute Hypoxia Signaling in the Rat Carotid Body. In: Wilson, D.F., Evans, S.M., Biaglow, J., Pastuszko, A. (eds) Oxygen Transport To Tissue XXIII. Advances in Experimental Medicine and Biology, vol 510. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0205-0_50
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DOI: https://doi.org/10.1007/978-1-4615-0205-0_50
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