Abstract
The survival of the retina and optic nerve is dependent on an adequate supply of oxygen and nutrients to fuel the metabolic processes that are vital for tissue homeostasis and primary visual function. Ocular diseases that affect the retina, including diabetic retinopathy, retinopathy of prematurity, glaucoma, and numerous proliferative retinopathies, are devastating diseases leading to major vision loss in humans. While the etiologies of these diseases are different, abnormalities in the delivery and consumption of oxygen are thought to be significant in all of them. Despite this common factor, quantitative studies that adequately correlate disease progression with changes in retinal oxygenation are lacking. In part, this is due to the almost complete absence of instrumentation for monitoring oxygenation in humans and the relatively few animal models that exhibit the full pathophysiology of these different retinal diseases.
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Shonat, R.D. (2003). Oxygen Delivery to the Retina and Related Visual Pathology. In: Wilson, D.F., Evans, S.M., Biaglow, J., Pastuszko, A. (eds) Oxygen Transport To Tissue XXIII. Advances in Experimental Medicine and Biology, vol 510. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0205-0_41
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DOI: https://doi.org/10.1007/978-1-4615-0205-0_41
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