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Neuronal Firing Patterns in the Subthalamic Nucleus

Effects of dopamine receptor stimulation on multisecond oscillations

  • Chapter
The Basal Ganglia VI

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 54))

Abstract

The subthalamic nucleus (STN) appears to play a critical role in mediating the hyper-and hypoactive behavioral states associated with basal ganglia pathophysiology8,11,15,17,37. Experiments designed to establish a more precise role for the STN have frequently been based on ‘dual-circuit’ models of basal ganglia motor circuitry7. These models predict that the neuronal firing rates of the STN will increase when dopamine cells of the substantia nigra pars compacta (SNc) degenerate, as occurs in Parkinson’s disease (PD). This increase in firing rate has been demonstrated in animal models of PD in both the rat and monkey 8,17,23. These models have had a profound impact on the development of effective treatment strategies for PD patients, leading to surgical procedures designed to attenuate the increase in STN neuronal firing rates. These procedures, which include high frequency stimulation and thermolytic lesion of the STN, significantly reduce the motor disturbances observed in human PD patients and in primate animal models of PD5,15.

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Author information

Authors and Affiliations

  1. Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA

    Kelly A. Allers, Judith R. Walters & Deborah S. Kreiss

  2. Department of Biology, University of Central Arkansas, 180 Lewis Science Center, Conway, AR, 72035, USA

    Deborah S. Kreiss

Authors
  1. Kelly A. Allers
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  2. Judith R. Walters
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  3. Deborah S. Kreiss
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Editor information

Editors and Affiliations

  1. Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Ann M. Graybiel

  2. Emory University, Atlanta, Georgia, USA

    Mahlon R. Delong

  3. University of Tennessee Memphis, Memphis, Tennessee, USA

    Stephen T. Kitai

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© 2002 Springer Science+Business Media New York

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Allers, K.A., Walters, J.R., Kreiss, D.S. (2002). Neuronal Firing Patterns in the Subthalamic Nucleus. In: Graybiel, A.M., Delong, M.R., Kitai, S.T. (eds) The Basal Ganglia VI. Advances in Behavioral Biology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0179-4_25

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  • DOI: https://doi.org/10.1007/978-1-4615-0179-4_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4955-6

  • Online ISBN: 978-1-4615-0179-4

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