Synonyms
Anaphylactic reaction; Anaphylactic shock; Anaphylactoid reaction; Life-threatening allergy
Definition
The historic nomenclature for anaphylaxis reserved the term “anaphylactic” for reactions mediated by immunoglobulin E (IgE) and the term “anaphylactoid” for reactions that were not IgE-mediated (Sampson et al. 2006). IgE-mediated and non-IgE-mediated reactions are, however, typically clinically indistinguishable. It is therefore now considered preferable to use the term “anaphylaxis,” irrespective of the mechanism involved. These reactions can then, if necessary, be subclassified as “immunologic” (i.e., IgE-mediated and non-IgE-mediated [e.g., IgG- and immune complex complement-mediated]) and “non-immunologic” (i.e., events resulting in sudden mast cell and basophil degranulation in the absence of immunoglobulins) reactions, as shown in Fig. 1 (Johansson et al. 2004).
Classifying allergic reactions using the example of asthma (Reprinted...
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Greenberger PA, Ditto AM. Chapter 24: anaphylaxis. Allergy Asthma Proc. 2012;33 Suppl 1:S80–3.
Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF, Motala C, Ortega Martell JA, Platts-Mills TA, Ring J, Thien F, Van Cauwenberge P, Williams HC. A revised nomenclature for allergy for global use: report of the nomenclature review committee of world allergy organization. J Allergy Clin Immunol. 2004;113:832–6.
Sampson HA, Muñoz-Furlong A, Campbell RL, Adkinson Jr NF, Bock SA, Branum A, Brown SG, Camargo Jr CA, Cydulka R, Galli SJ, Gidudu J, Gruchalla RS, Harlor Jr AD, Hepner DL, Lewis LM, Lieberman PL, Metcalfe DD, O’Connor R, Muraro A, Rudman A, Schmitt C, Scherrer D, Simons FE, Thomas S, Wood JP, Decker WW. Second symposium on the definition and management of anaphylaxis: summary report-Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol. 2006;117:391–7.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
Panesar, S.S., Sheikh, A. (2014). Pathophysiology of Anaphylaxis. In: Mackay, I.R., Rose, N.R., Ledford, D.K., Lockey, R.F. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9194-1_588
Download citation
DOI: https://doi.org/10.1007/978-1-4614-9194-1_588
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-9193-4
Online ISBN: 978-1-4614-9194-1
eBook Packages: MedicineReference Module Medicine