Abstract
Gastroesophageal reflux refers to the reflux of gastric contents into the esophagus in an otherwise healthy infant. Gastroesophageal reflux is a commonly diagnosed problem in critically ill infants in the neonatal intensive care unit which may progress to gastroesophageal reflux disease. Gastroesophageal reflux disease is a more serious condition characterized by chronic symptoms of mucosal damage. The causes and risk factors for developing gastroesophageal reflux disease and its associated complications are identified. The range of diagnostic investigations and the efficacy and safety of current treatments that may be undertaken in the critically ill infant are also discussed in this chapter.
Abbreviations
- GOR:
-
Gastroesophageal reflux
- GORD:
-
Gastroesophageal reflux disease
- NICU:
-
Neonatal intensive care unit
- PPIs:
-
Proton pump inhibitors
- TLOSR:
-
Transient lower esophageal sphincter relaxation
References
Birch JL, Newell SJ. Gastroesophageal reflux disease in preterm infants current management and diagnostic dilemmas. Arch Dis Child Fetal Neonatal Ed. 2009;94:F379–83.
Corvaglia L, Zama D, Gualdi S, Ferlini M, Aceti A, Faldella G. Gastroesophageal reflux increases the number of apnoeas in very preterm infants. Arch Dis Child Fetal Neonatal Ed. 2009;94:F188–92.
Corvaglia L, Zama D, Spizzichino M, Aceti A, Mariani E, Capretti MG, Faldella G. The frequency of apneas in very preterm infants is increased after non-acid gastro-esophageal reflux. Neurogastroenterol Motil. 2011;23(4):303–7.
Crump C, Winkleby M, Sundquist J, Sundquist K. Gestational age at birth and risk of gastric acid-related disorders in young adulthood. Ann Epidemiol. 2012;22:233–8.
Di Fiore J, Arko M, Herynk B, Martin R, Hibbs AM. Characterization of cardiorespiratory events following gastroesophageal reflux in preterm infants. J Perinatol. 2010;30:683–7.
Eisen GM. The epidemiology of gastroesophageal reflux disease: what we know and what we need to know. Am J Gastroenterol. 2001;96 Suppl 8:S16–8.
Hallal C, Manica D, Chaves VS, Marostica P, Trotta EA, Carvalho PA, Goldani HAS. Acid and non-acid gastroesophageal reflux in critically ill mechanically ventilated and tube-fed infants. Arch Dis Child. 2012;97(A15).
Hegar B, Dewanti NR, Kadim M, Alatas S, Firmansyah A, Vandenplas Y. Natural evolution of regurgitation in healthy infants. Acta Paediatr. 2009;98(7):1189–93.
Horvath A, Dziechciarz P, Szajewska H. The effect of thickened feed interventions on gastroesophageal reflux in infants:systematic review and meta-analysis of randomized, controlled trials. Pediatrics. 2008;122:e1268–77.
Huang R, Forbes D, Davies MW. Feed thickener for newborn infants with gastro-oesophageal reflux. Cochrane Database Syst Rev. 2002;3. doi:10.1002/14651858.CD003211.
Jadcherla SR. Gastrointestinal reflux. In: Thureen P, Hay W, editors. Neonatal nutrition and metabolism. Cambridge: Cambridge University Press; 2006.
Jadcherla SR, Chan CY, Moore R, Malkar M, Timan CJ, Valentine CJ. Impact of feeding strategies on the frequency and clearance of acid and nonacid gastroesophageal reflux events in dysphagic neonates. J Parenter Enter Nutr. 2011;36:449. doi:10.1177/0148607111415980.
Kahrilas PJ. GERD pathogenesis, pathophysiology, and clinical manifestations. Clevel Clin J Med. 2003;70:S4–19.
Kaijser M, Akre O, Cnattingius S, Ekbom A. Preterm birth, low birth weight, and risk for esophageal adenocarcinoma. Gastroenterol Nurs. 2005;128:607–9.
Kentrup H, Baisch H, Kusenbach G, Heimann G, Skopnik H. Effect of cisapride on acid gastro-oesophageal reflux during treatment with caffeine. Biol Neonate. 2000;77:92–5.
Khan S, Orenstein SR. Gastroesophageal reflux disease. In: Kliegman RM, Stanton BG, Geme JW, Schor NF, Behrman RE, editors. Nelson textbook of pediatrics. 19th ed. Philadelphia: Elsevier Saunders; 2011. p. 1266–70.
Kultursay N. Gastroesophageal reflux (GER) in preterms: current dilemmas and unresolved problems in diagnosis and treatment. Turk J Pediatr. 2012;54:561–9.
Lightdale JR, Gremse DA. Gastroesophageal reflux: management guidance for the pediatrician. Pediatrics. 2013;131(5):e1684–895. doi:10.1542/peds.2013-0421.
Macharia EW, Eaton S, de Coppi P, Curry J, Drake D, Cross K, Pierro A. Fundoplication in ventilator-dependent infants with gastro-oesophageal reflux. Eur J Pediatr Surg. 2012;22:91–6.
Mathai SS, Datta K, Adhikari KM. A study of the effect of nasal modes of ventilation on the incidence of gastro-oesophageal reflux in preterm neonates. Med J Armed Forces India (MJAFI). 2012;68:12–5.
Mendes TB, Mezzacappa MS, Torro AA, Ribeiro JD. Risk factors for gastroesophageal reflux disease in very low birth weight infants with bronchopulmonary dysplasia. J Pediatr. 2008;84(2):154–9.
Mousa HM, Rosen R, Woodley FW, Orsi M, Armas D, Faure C, Nurko S. Esophageal impedance monitoring for gastroesophageal reflux. J Pediatr Gastroenterol Nutr. 2011;52:129–39.
Neu M, Corwin E, Lareau SC, Marcheggiani-Howard C. A review of nonsurgical treatment for the symptom of irritability in infants with GERD. J Spec Pediatr Nurs. 2012;17(3):177–92. doi:10.1111/j.1744-6155.2011.00310.x.
Nind G, Chen W, Protheroe R, Iwakiri K, Fraser R, Holloway RH. Mechanisms of gastroesophageal reflux in critically ill mechanically ventilated patients. Gastroenterology. 2005;128(3):600–6.
Omari TI, Barnett CP, Benninga MA, Lontis R, Goodchild L, Haslam RR, Dent J, Davidson GP. Mechanisms of gastro-oesophageal reflux in preterm and term infants with reflux disease. Gut. 2002;51(4):475–9.
Orenstein SR. Regurgitation & GERD. J Pediatr Gastroenterol Nutr. 2002;32:S16–8.
Orenstein SR, Shalaby TM, Cohn J. Reflux symptoms in 100 normal infants: diagnostic validity of the infant gastroesophageal reflux questionnaire. Clin Pediatr. 1996;35:607–14.
Peter CS, Sprodowski N, Bohnhorst B, Silny J, Poets CF. Gastroesophageal reflux and apnea of prematurity: no temporal relationship. Pediatrics. 2002a;109:8–11.
Peter CS, Wiechers C, Bohnhorst B, Silny J, Poets CF. Influence of nasogastric tubes on gastroesophageal reflux in preterm infants: a multiple intraluminal impedance study. J Pediatr. 2002b;141:277–9.
Pinelli J, Symington AJ. Non-nutritive sucking for promoting physiologic stability and nutrition in preterm infants. Cochrane Database Syst Rev. 2005;4. doi:10.1002/14651858.CD001071.
Psaila K, Foster J, Richards R, Jeffery HE. Non-nutritive sucking for gastro-oesophageal reflux disease in preterm and low birth weight infants. CochraneDatabase Syst Rev. 2012;4. doi:10.1002/14651858.CD009817.
Ramirez A, Wong WW, Shulman RJ. Factors regulating gastric emptying in preterm infants. J Pediatr. 2006;149:475–9.
Thompson D. Laryngomalacia: factors that influence disease severity and outcomes of management. Curr Opin Otolaryngol Head Neck Surg. 2012;18:564–70.
Vandenplas Y, Rudolph CD. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr. 2009;49:498–547.
Volonaki E, Sebire NJ, Borrelli O. Gastrointestinal endoscopy and mucosal biopsy in the first year of life: indications and outcome. J Pediatr Gastroenterol Nutr. 2012;55(1):62–5.
Watson J, McGuire W. Transpyloric versus gastric tube feeding for preterm infants. Cochrane Database Syst Rev. 2013;2. doi:10.1002/14651858.CD003487.pub3.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media New York
About this entry
Cite this entry
Psaila, K., Foster, J.P., Atlantis, E. (2014). Critically Ill Infants with Gastroesophageal Reflux Disease. In: Rajendram, R., Preedy, V., Patel, V. (eds) Diet and Nutrition in Critical Care. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8503-2_101-1
Download citation
DOI: https://doi.org/10.1007/978-1-4614-8503-2_101-1
Received:
Accepted:
Published:
Publisher Name: Springer, New York, NY
Online ISBN: 978-1-4614-8503-2
eBook Packages: Springer Reference MedicineReference Module Medicine
Publish with us
Chapter history
-
Latest
Critically Ill Infants with Gastroesophageal Reflux Disease- Published:
- 31 December 2014
DOI: https://doi.org/10.1007/978-1-4614-8503-2_101-2
-
Original
Critically Ill Infants with Gastroesophageal Reflux Disease- Published:
- 29 October 2014
DOI: https://doi.org/10.1007/978-1-4614-8503-2_101-1