Abstract
Skin cancer is the most frequent form of cancer in human beings and the sonographic imaging support of the primary lesion can provide relevant anatomical data that can improve the prognosis of patients and decrease recurrences. The most frequent types of skin cancer are discussed and include basal cell carcinoma, squamous cell carcinoma, and melanoma. Information on the sonographic morphology, contrast-enhanced ultrasound, and sonoelastography of skin cancer is provided. Other types of malignant skin tumors such as dermatofibrosarcoma protuberans, Merkel cell carcinoma, and cutaneous lymphomas are also covered.
How to deal and what to look for in the primary lesion
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Hong H, Sun J, Cai W. Anatomical and molecular imaging of skin cancer. Clin Cosmet Investig Dermatol. 2008;1:1–17.
Bartoš V, Pokorný D, Zacharová O, Haluska P, Doboszová J, Kullová M, et al. Recurrent basal cell carcinoma: a clinicopathological study and evaluation of histomorphological findings in primary and recurrent lesions. Acta Dermatovenerol Alp Panonica Adriat. 2011;20:67–75.
Goto M, Kai Y, Arakawa S, Oishi M, Ishikawa K, Anzai S, et al. Analysis of 256 cases of basal cell carcinoma after either one-step or two-step surgery in a Japanese institution. J Dermatol. 2012;39:68–71.
Brenn T, Mc Kee P. Tumors of the surface epithelium. In: Mc Kee P, Calonje E, Granter S, editors. Pathology of the skin with clinical correlations. 3rd ed. Philadelphia: Elsevier/Mosby; 2005. p. 1167–82.
Samarasinghe V, Madan V, Lear JT. Management of high-risk squamous cell carcinoma of the skin. Expert Rev Anticancer Ther. 2011;11:763–9.
Veness MJ. High-risk cutaneous squamous cell carcinoma of the head and neck. J Biomed Biotechnol. 2007;2007(3):80572.
Brenn T, Mc Kee P. Tumors of the surface epithelium. In: Mc Kee P, Calonje E, Granter S, editors. Pathology of the skin with clinical correlations. 3rd ed. Philadelphia: Elsevier/Mosby; 2005. p. 1199–228.
Gniadecki R, Normal DT. Basal cell carcinoma—clinical guidelines, Danish dermatological society. Forum for Nord Derm Ven. 2009;14(1):4–6.
Zavos G, Karidis NP, Tsourouflis G, Bokos J, Diles K, Sotirchos G, et al. Nonmelanoma skin cancer after renal transplantation: a single-center experience in 1736 transplantations. Int J Dermatol. 2011;50:1496–500.
Yuen WY, Jonkman MF. Risk of squamous cell carcinoma in junctional epidermolysis bullosa, non-Herlitz type: report of 7 cases and a review of the literature. J Am Acad Dermatol. 2011;65:780–9.
Huang L, Wong YP, Burd A. A novel homozygous splice site mutation in COL7A1 in a Chinese patient with severe recessive dystrophic epidermolysis bullosa and squamous cell carcinoma. Int J Dermatol. 2011;50:52–6.
Bobadilla F, Wortsman X, Muñoz C, Segovia L, Espinoza M, Jemec GB. Pre-surgical high resolution ultrasound of facial basal cell carcinoma: correlation with histology. Cancer Imaging. 2008;8:163–72.
Uhara H, Hayashi K, Koga H, Saida T. Multiple hypersonographic spots in basal cell carcinoma. Dermatol Surg. 2007;33:1215–9.
Ekwueme DU, Guy G, Li C, Rim SH, Parelkar P, Chen SC. The health burden and economic costs of cutaneous melanoma mortality by race/ethnicity-United States, 2000 to 2006. J Am Acad Dermatol. 2011;6(S1):S133–43.
Reintgen DS, Vollmer R, Tso CY, Seigler HF. Prognosis for recurrent stage I malignant melanoma. Arch Surg. 1987;122:1338–42.
Nazarian LN, Alexander AA, Kurtz AB, Capuzzi Jr DM, Rawool NM, Gilbert KR, et al. Superficial melanoma metastases: appearances on gray-scale and color Doppler sonography. AJR Am J Roentgenol. 1998;170:459–63.
Netscher DT, Leong M, Orengo I, Yang D, Berg C, Krishnan B. Cutaneous malignancies: melanoma and nonmelanoma types. Plast Reconstr Surg. 2011;127:37e–56.
McKee P, Calonje E, Granter S. Melanoma. In: MacKee P Calonje E, Granter S. editors. Pathology of the skin with clinical correlations. 3rd ed. Philadelphia: Elsevier/Mosby; 2005. p. 1309–56.
Wortsman X. Sonography of the primary cutaneous melanoma: a review. Radiol Res Pract. 2012;2012:814396.
Tacke J, Haagen G, Horstein O, Huettinger G, Kiesewetter F, Schell H, et al. Clinical relevance of sonometry-derived tumour thickness in malignant melanoma—a statistical analysis. Br J Dermatol. 1995;132:209–14.
Guitera P, Li LX, Crotty K, Fitzgerald P, Mellenbergh R, Pellacani G, et al. Melanoma histological Breslow thickness predicted by 75-MHz ultrasonography. Br J Dermatol. 2008;159:364–9.
Hoffmann K, Jung J, el Gammal S, Altmeyer P. Malignant melanoma in 20-MHz B scan sonography. Dermatology. 1992;185:49–55.
Kaikaris V, Samsanavičius D, Maslauskas K, Rimdeika R, Valiukevičienė S, Makštienė J, et al. Measurement of melanoma thickness–comparison of two methods: ultrasound versus morphology. J Plast Reconstr Aesthet Surg. 2011;64:796–802.
Catalano O, Siani A. Cutaneous melanoma: role of ultrasound in the assessment of locoregional spread. Curr Probl Diagn Radiol. 2010;39:30–6.
Vilana R, Puig S, Sanchez M, Squarcia M, Lopez A, Castel T, et al. Preoperative assessment of cutaneous melanoma thickness using 10-MHz sonography. AJR Am J Roentgenol. 2009;193:639–43.
Music MM, Hertl K, Kadivec M, Pavlović MD, Hocevar M. Pre-operative ultrasound with a 12–15 MHz linear probe reliably differentiates between melanoma thicker and thinner than 1 mm. J Eur Acad Dermatol Venereol. 2010;24:1105–8.
Lassau N, Mercier S, Koscielny S, Avril MF, Margulis A, Mamelle G, et al. Prognostic value of high-frequency sonography and color doppler sonography for the preoperative assessment of melanomas. AJR Am J Roentgenol. 1999;172:457–61.
Lassau N, Koscielny S, Avril MF, Margulis A, Duvillard P, De Baere T, et al. Prognostic value of angiogenesis evaluated with high-frequency and color Doppler sonography for preoperative assessment of melanomas. AJR Am J Roentgenol. 2002;178:1547–51.
Lassau N, Spatz A, Avril MF, Tardivon A, Margulis A, Mamelle G, et al. Value of high-frequency US for preoperative assessment of skin tumors. Radiographics. 1997;17:1559–65.
Voit C, Van Akkooi AC, Schäfer-Hesterberg G, Schoengen A, Kowalczyk K, Roewert JC, et al. Ultrasound morphology criteria predict metastatic disease of the sentinel nodes in patients with melanoma. J Clin Oncol. 2010;28:847–52.
Nazarian LN, Alexander AA, Rawool NM, Kurtz AB, Maguire HC, Mastrangelo MJ. Malignant melanoma: impact of superficial US on management. Radiology. 1996;199:273–7.
Catalano O, Voit C, Sandomenico F, Mandato Y, Petrillo M, Franco R, et al. Previously reported sonographic appearances of regional melanoma metastases are not likely due to necrosis. J Ultrasound Med. 2011;30:1041–9.
Tombesi P, Tassinari D, Sartori S. Contrast-enhanced ultrasound for characterizing lymph nodes with focal cortical thickening in patients with cutaneous melanoma. AJR Am J Roentgenol. 2011;197:W371.
Rubaltelli L, Beltrame V, Tregnaghi A, Scagliori E, Frigo AC, Stramare R. Contrast-enhanced ultrasound for characterizing lymph nodes with focal cortical thickening in patients with cutaneous melanoma. AJR Am J Roentgenol. 2011;196:W8–12.
Lassau N, Chami L, Chebil M, Benatsou B, Bidault S, Girard E, et al. Dynamic contrast-enhanced ultrasonography (DCE-US) and anti-angiogenic treatments. Discov Med. 2011;11:18–24.
Forsberg F, Ro RJ, Liu JB, Lipcan KJ, Potoczek M, Nazarian LN. Monitoring angiogenesis in human melanoma xenograft model using contrast-enhanced ultrasound imaging. Ultrason Imaging. 2008;30:237–46.
Goldberg BB, Merton DA, Liu JB, Forsberg F, Zhang K, Thakur M, et al. Contrast-enhanced ultrasound imaging of sentinel lymph nodes after peritumoral administration of Sonazoid in a melanoma tumor animal model. J Ultrasound Med. 2011;30:441–53.
Bhatia KS, Yuen EH, Cho CC, Tong CS, Lee YY, Ahuja ATA. Pilot study evaluating real-time shear wave ultrasound elastography of miscellaneous non-nodal neck masses in a routine head and neck ultrasound clinic. Ultrasound Med Biol. 2012;38:933–42.
Hinz T, Wenzel J, Schmid-Wendtner MH. Real-time tissue elastography: a helpful tool in the diagnosis of cutaneous melanoma? J Am Acad Dermatol. 2011;65:424–6.
Kirkpatrick SJ, Wang RK, Duncan DD, Kulesz-Martin M, Lee K. Imaging the mechanical stiffness of skin lesions by in vivo acousto-optical elastography. Opt Express. 2006;14:9770–9.
Rouffiac V, Duret JS, Péronneau P, Dehez N, Opolon P, Roche A, et al. Combination of HIFU therapy with contrast-enhanced sonography for quantitative assessment of therapeutic efficiency on tumor grafted mice. Ultrasound Med Biol. 2006;32:729–40.
Xing Y, Lu X, Pua EC, Zhong P. The effect of high intensity focused ultrasound treatment on metastases in a murine melanoma model. Biochem Biophys Res Commun. 2008;375:645–50.
Oliveira-Soares R, Viana I, Vale E, Soares-Almeida LM, Picoto A. Dermatofibrosarcoma protuberans: a clinicopathological study of 20 cases. J Eur Acad Dermatol Venereol. 2002;16:441–6.
Nouri K, Lodha R, Jimenez G, Robins P. Mohs micrographic surgery for dermatofibrosarcoma protuberans: University of Miami and NYU experience. Dermatol Surg. 2002;28:1060–4.
Thornton SL, Reid J, Papay FA, Vidimos AT. Childhood dermatofibrosarcoma protuberans: role of preoperative imaging. J Am Acad Dermatol. 2005;53:76–83.
Shin YR, Kim JY, Sung MS, Jung JH. Sonographic findings of dermatofibrosarcoma protuberans with pathologic correlation. J Ultrasound Med. 2008;27:269–74.
Donghi D, Kerl K, Dummer R, Schoenewolf N, Cozzio A. Cutaneous angiosarcoma: own experience over 13 years. Clinical features, disease course and immunohistochemical profile. J Eur Acad Dermatol Venereol. 2010;24:1230–4.
Wollina U, Hansel G, Schönlebe J, Averbeck M, Paasch U, Uhl J, et al. Cutaneous angiosarcoma is a rare aggressive malignant vascular tumour of the skin. J Eur Acad Dermatol Venereol. 2011;25:964–8.
Morgan MB, Swann M, Somach S, Eng W, Smoller B. Cutaneous angiosarcoma: a case series with prognostic correlation. J Am Acad Dermatol. 2004;50:867–74.
Kamo R, Ishii M. Histological differentiation, histogenesis and prognosis of cutaneous angiosarcoma. Osaka City Med J. 2011;57:31–44.
Costache M, Ene AM, Simionescu O, Sajin M. Histopathological diagnosis of cutaneous vascular sarcomas. Rom J Morphol Embryol. 2010;51:105–9.
Gasparetto TD, Marchiori E, Lourenço S, Zanetti G, Vianna AD, Santos AA, et al. Pulmonary involvement in Kaposi sarcoma: correlation between imaging and pathology. Orphanet J Rare Dis. 2009;4:18.
Restrepo CS, Ocazionez D. Kaposi’s sarcoma: imaging overview. Semin Ultrasound CT MR. 2011;32:456–69.
Requena L, Requena C. Histopathology of the more common viral skin infections. Actas Dermosifiliogr. 2010;101:201–16.
Solivetti FM, Elia F, Latini A, Cota C, Cordiali-Fei P, Di Carlo A. AIDS-kaposi sarcoma and classic kaposi sarcoma: are different ultrasound patterns related to different variants? J Exp Clin Cancer Res. 2011;30:40.
Haddow LJ, Davies S, Buckingham S, Miller RF. Kaposi’s sarcoma infiltrating skeletal muscle. Sex Transm Infect. 2002;78:464–5.
Bogner JR, Zietz C, Held M, Späthling S, Sandor P, Kronawitter U, et al. Ultrasound as a tool to evaluate remission of cutaneous Kaposi’s sarcoma. AIDS. 1993;7:1081–5.
Duprat JP, Landman G, Salvajoli JV, Brechtbühl ER. A review of the epidemiology and treatment of Merkel cell carcinoma. Clinics (Sao Paulo). 2011;66:1817–23.
Nicolaidou E, Mikrova A, Antoniou C, Katsambas AD. Advances in Merkel cell carcinoma pathogenesis and management: a recently discovered virus, a new international consensus staging system and new diagnostic codes. Br J Dermatol. 2012;166:16–21.
Pileri Jr A, Patrizi A, Agostinelli C, Neri I, Sabattini E, Bacci F, et al. Primary cutaneous lymphomas: a reprisal. Semin Diagn Pathol. 2011;28:214–33.
Galper SL, Smith BD, Wilson LD. Diagnosis and management of mycosis fungoides. Oncology (Williston Park). 2010;24:491–501.
McKee P, Calonje E, Granter S. Cutaneous lymphoproliferative diseases and related disorders. In: MacKee P Calonje E, Granter S, editors. Pathology of the skin with clinical correlations. 3rd ed. Philadelphia: Elsevier/Mosby; 2005. p. 1357–457.
Oztürk E, Sipahioglu S, Han U, Yücesoy C, Dilli A, Hekimoğlu B. Ultrasonography and MRI findings of cutaneous B-cell lymphoma, leg type. JBR-BTR. 2011;94:81–2.
Ushiki T, Nikkuni K, Higuchi T, Takai K. Multimodality imaging of subcutaneous panniculitis-like T-cell lymphoma. Intern Med. 2011;50:1265.
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Wortsman, X., Carreño, L., Morales, C. (2013). Skin Cancer: The Primary Tumors. In: Wortsman, X. (eds) Dermatologic Ultrasound with Clinical and Histologic Correlations. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7184-4_9
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DOI: https://doi.org/10.1007/978-1-4614-7184-4_9
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