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Nerve and Muscle Biopsies

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Book cover Neuromuscular Disorders in Clinical Practice

Abstract

Muscle biopsies are essential in the diagnosis of primary diseases of muscle. Nerve biopsies, while less commonly employed for diagnosis, remain essential in specific cases. Proper technique in preparation of the specimen and an understanding of the clinical picture is essential in interpretation of the biopsy. This chapter provides an introduction to techniques for muscle and nerve biopsy preparation and examination. The microanatomy and appearance of normal muscle and nerve are presented. The findings present in axonal and demyelinating neuropathies, and specific nerve and muscle diseases are discussed.

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Author information

Authors and Affiliations

  1. Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA

    J. Douglas Miles MD, PhD

  2. Neurohospitalist and Neuroscience Education, The Queen’s Medical Center, Honolulu, HI, USA

    J. Douglas Miles MD, PhD

  3. Department of Pathology, University Hospitals Case Medical Center, Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA

    Mark L. Cohen MD

Authors
  1. J. Douglas Miles MD, PhD
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  2. Mark L. Cohen MD
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Corresponding author

Correspondence to J. Douglas Miles MD, PhD .

Editor information

Editors and Affiliations

  1. School of Medicine Department of Neurology, University Hospitals Case Medical Center Case Western Reserve University, Cleveland, Ohio, USA

    Bashar Katirji

  2. Department of Neurology, George Washington University, Washington, District of Columbia, USA

    Henry J. Kaminski

  3. University School of Medicine Department of Neurology, Louis Stokes Cleveland VA Medical Center Case Western Reserve, Cleveland, Ohio, USA

    Robert L. Ruff

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Miles, J.D., Cohen, M.L. (2014). Nerve and Muscle Biopsies. In: Katirji, B., Kaminski, H., Ruff, R. (eds) Neuromuscular Disorders in Clinical Practice. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6567-6_12

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  • DOI: https://doi.org/10.1007/978-1-4614-6567-6_12

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