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CDC73

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 61 Accesses

Synonyms

C1orf28 ; HRPT2 ; Hyrax ; parafibromin

Historical Background

Knowledge of mammalian CDC73 has essentially been driven by focused efforts to map, and then characterize, a gene responsible for familial primary hyperparathyroidism. Primary hyperparathyroidism (HPT) is estimated to affect three in every 1000 people. Primary HPT refers to hypersecretion of parathyroid hormone (PTH) by chief cells in the parathyroid in a setting of disrupted calcium homeostasis. Sporadic HPT is caused by the presence of a single parathyroid adenoma in the majority of patients (80–85%) or hyperplasia that affects more than one gland in 15–20% of patients. Sporadic parathyroid carcinoma is an exceedingly rare tumor, responsible for <1% of cases of primary HPT. Parathyroid abnormalities can also present as components of the familial syndrome Hyperparathyroidism Jaw Tumor syndrome (HPT-JT). Abnormalities that are part of the HPT-JT phenotype include parathyroid carcinoma (10–15%), fibro-osseous tumors...

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References

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Authors and Affiliations

  1. Hormones and Cancer Division, Kolling Institute of Medical Research, University of Sydney and Royal North Shore Hospital, Sydney, NSW, Australia

    Deborah J Marsh

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  1. Deborah J Marsh
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Correspondence to Deborah J Marsh .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Marsh, D.J. (2016). CDC73. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101660-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101660-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

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