Skip to main content

Retinoid Embryopathy

  • Living reference work entry
  • First Online:
Atlas of Genetic Diagnosis and Counseling
  • 153 Accesses

Abstract

Oral retinoids, isotretinoin (Accutane), and etretinate, uniquely effective in the treatment for severe cystic and keratinization disorders, are potent human teratogens.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Abroms, L., Maibach, E., Lyon-Daniel, K., et al. (2006). What is the best approach to reducing birth defects associated with isotretinoin? PLoS Medicine, 3, e483.

    Article  PubMed  PubMed Central  Google Scholar 

  • Altman, E. M. (2014). Isotretinoin and pregnancy prevention: Do we need to take a long, hard look at ourselves? JAMA Dermatology, 150, 361–362.

    Article  PubMed  Google Scholar 

  • Atanackovic, G., & Koren, G. (1999a). Fetal exposure to oral isotretinoin: Failure to comply with the Pregnancy Prevention Program. Canadian Medical Association Journal, 160, 1719–1720.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Atanackovic, G., & Koren, G. (1999b). Young women taking isotretinoin still conceive. Role of physicians in preventing disaster. Canadian Family Physician, 45, 289–292.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Braun, J. T., Franciosi, R. A., Mastri, A. R., et al. (1984). Isotretinoin dysmorphic syndrome. Lancet, 1, 506–507.

    Article  CAS  PubMed  Google Scholar 

  • Brinker, A., Trontell, A., & Beitz, J. (2002). Pregnancy and pregnancy rates in association with isotretinoin (Accutane). Journal of the American Academy of Dermatology, 47, 798–799.

    Article  PubMed  Google Scholar 

  • Chan, A., Hanna, M., Abbott, M., et al. (1996). Oral retinoids and pregnancy. The Medical Journal of Australia, 165, 164–167.

    CAS  PubMed  Google Scholar 

  • Choi, J. S., Koren, G., & Nulman, I. (2013). Pregnancy and isotretinoin therapy. Canadian Medical Association Journal, 185, 411–413.

    Article  PubMed  PubMed Central  Google Scholar 

  • Collins, M.-K., Moreau, J. F., Opel, D., et al. (2014). Compliance with pregnancy prevention measures during isotretinoin therapy. Journal of American Academy of Dermatology, 70, 55–59.

    Article  Google Scholar 

  • Crijns, H. J. M. J., Staus, S. M., Gispen-de Wied, C. H., et al. (2011). Compliance with pregnancy prevention programs of isotretinoin in Europe: A systemic review. British Journal of Dermatology, 164, 238–244.

    Article  CAS  PubMed  Google Scholar 

  • Dai, W. S., Hsu, M. A., & Itri, L. M. (1989). Safety of pregnancy after discontinuation of isotretinoin. Archives of Dermatology, 125, 362–365.

    Article  CAS  PubMed  Google Scholar 

  • de la Cruz, E., Sun, S., Vangvanichyakorn, K., et al. (1984). Multiple congenital malformations associated with maternal isotretinoin therapy. Pediatrics, 74, 428–430.

    PubMed  Google Scholar 

  • Ellis, C. N., & Krach, K. J. (2001). Uses and complications of isotretinoin therapy. Journal of the American Academy of Dermatology, 45, S150–S157.

    Article  CAS  PubMed  Google Scholar 

  • Fernhoff, P. M., & Lammer, E. J. (1984). Craniofacial features of isotretinoin embryopathy. Journal of Pediatrics, 105, 595–597.

    Article  CAS  PubMed  Google Scholar 

  • Goldsmith, L. A., Bolognia, J. L., Callen, J. P., et al. (2004). American Academy of Dermatology Consensus Conference on the safe and optimal use of isotretinoin: Summary and recommendations. Journal of the American Academy of Dermatology, 50, 900–906.

    Article  PubMed  Google Scholar 

  • Henry, D., Dormuth, C., Winquist, B., et al. (2016). Occurrence of pregnancy and pregnancy outcomes during isotretinoin therapy. Canadian Medical Association Journal, 188, 723–730.

    Article  PubMed  PubMed Central  Google Scholar 

  • Holmes, S. C., Bankowska, U., & Mackie, R. M. (1998). The prescription of isotretinoin to women: Is every precaution taken? British Journal of Dermatology, 138, 450–455.

    Article  CAS  PubMed  Google Scholar 

  • Jahn, A. F., & Ganti, K. (1987). Major auricular malformations due to Accutane (isotretinoin). Laryngoscope, 97, 832–835.

    Article  CAS  PubMed  Google Scholar 

  • Koren, G., & Pastuszak, A. (1997). How to ensure fetal safety when mothers use isotretinoin (Accutane). Canadian Family Physician, 43, 216–219.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lammer, E. J., Schunior, A., Hayes, A. M., et al. (1988). Isotretinoin dose and teratogenicity. Lancet, 2, 503–504.

    Article  CAS  PubMed  Google Scholar 

  • Lancaster, P. A. (1988). Teratogenicity of isotretinoin. Lancet, 2, 1254–1255.

    Article  CAS  PubMed  Google Scholar 

  • Mitchell, A. A., & Van Bennekom, C. M. (2003). Accutane and pregnancy. Journal of the American Academy of Dermatology, 49, 1201–1202.

    Article  PubMed  Google Scholar 

  • Mitchell, A. A., Van Bennekom, C. M., & Louik, C. (1995). A pregnancy-prevention program in women of childbearing age receiving isotretinoin. The New England Journal of Medicine, 333, 101–106.

    Article  CAS  PubMed  Google Scholar 

  • Panchaud, A., Csajka, C., Merlob, P., et al. (2012). Pregnancy outcome following exposure to topical retinoids: A multicenter prospective study. Journal of Clinical Pharmacology, 52, 1844–1851.

    Article  CAS  PubMed  Google Scholar 

  • Pastuszak, A., & Koren, G. (1993). The retinoid pregnancy prevention program. In G. Koren (Ed.), Retinoids in clinical practice. The risk-benefit ratio (pp. 147–175). New York: Marcel Dekker.

    Google Scholar 

  • Pastuszak, A., Koren, G., & Rieder, M. J. (1994). Use of the retinoid pregnancy prevention program in Canada: Patterns of contraception use in women treated with isotretinoin and etretinate. Reproductive Toxicology, 8, 63–68.

    Article  CAS  PubMed  Google Scholar 

  • Perlman, S. E., Leach, E. E., Dominguez, L., et al. (2001). Be smart, be safe, be sure. The revised Pregnancy Prevention Program for women on isotretinoin. Journal of Reproductive Medicine, 46, 179–185.

    CAS  PubMed  Google Scholar 

  • Rademaker, M. (2010). Adverse effects of isotretinoin: A retrospective review of 1743 patients started on isotretinoin. Australasian Journal of Dermatology, 51, 248–253.

    Article  PubMed  Google Scholar 

  • Rizzo, R., Lammer, E. J., Parano, E., et al. (1991). Limb reduction defects in humans associated with prenatal isotretinoin exposure. Teratology, 44, 599–604.

    Article  CAS  PubMed  Google Scholar 

  • Sarici, D., Akin, M. A., Kurtoglu, S., et al. (2012). Asymmetric crying face in a newborn with isotretinoin embryopathy. Pediatric Dermatology, 30, e289–e290.

    Article  PubMed  Google Scholar 

  • Shear, N. H. (1999). Oral isotretinoin: Prescribers beware. Canadian Medical Association Journal, 160, 1723–1724.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Stashower, M. E. (2003). Pregnancy rates associated with isotretinoin (Accutane) and the FDA. Journal of the American Academy of Dermatology, 49, 1202–1203.

    Article  PubMed  Google Scholar 

  • Strauss, J. S., Cunningham, W. J., Leyden, J. J., et al. (1988). Isotretinoin and teratogenicity. Journal of the American Academy of Dermatology, 19, 353–354.

    Article  CAS  PubMed  Google Scholar 

  • Werner, C. A., Papic, M. J., Ferris, L. K., et al. (2014). Women’s experiences with isotretinoin risk reduction counseling. JAMA Dermatology, 150, 366–371.

    Article  PubMed  Google Scholar 

  • Zomerdijk, I. M., Ruiter, R., Houweling, L. M. A., et al. (2014). Isotretinoin exposure during pregnancy: A population-based study in The Netherlands. BMJ Open, 4, 1–7.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Harold Chen .

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media LLC

About this entry

Cite this entry

Chen, H. (2016). Retinoid Embryopathy. In: Atlas of Genetic Diagnosis and Counseling. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6430-3_201-2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6430-3_201-2

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6430-3

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics