Necrolytic Migratory Erythema

Abstract

Clinical signs and features include:

Rare dermatitis that occurs mostly in patients with α-cell tumor of the pancreas (glucagonoma) that usually occurs in the fifth to sixth decade and presents with frequency of 1:20,000,000 persons/year

Rash comes in waves of irregular erythematous lesions with visible scale with subsequent necrosis and crusting of the epidermis in the center of the lesions leading to bullae

Central healing ultimately occurs giving the lesions an annular appearance; the process for development to healing is about 2 weeks

Predilection for intertriginous sites and areas subject to pressure and frictions (e.g., perineum, groin, buttocks, lower abdomen, and lower extremities)