Abstract
The ongoing search for specialty substances with unique physical and chemical properties has motivated the development of numerous types of metal oxide nanomaterials, but concerns remain regarding biological effects of particles that are comparable in size to ultrafine air pollution (d < 100 nm). Much of the nanoparticle toxicological research has been on inhalation and intact-skin dermal exposures. Lung epithelial cells exposed to oxide nanoparticles show diverse responses, most notably upregulation of pro-inflammatory signaling pathways. This chapter addresses potential etiologies, mechanisms, and methodologies for investigating potential unforeseen toxicities of nanoparticles that are likely to occur in skin as nanoproducts become more and more available.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Song Y, Li X, Du X. Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma. Eur Respir J. 2009;34(3):559–67.
Song Y, Tang S. Nanoexposure, unusual diseases, and new health and safety concerns. ScientificWorldJournal. 2011;11:1821–8.
Monteiro-Riviere NA, Wiench K, Landsiedel R, Schulte S, Inman AO, Riviere JE. Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: an in vitro and in vivo study. Toxicol Sci. 2011;123(1):264–80.
Moos PJ, Olszewski K, Honeggar M, et al. Responses of human cells to ZnO nanoparticles: a gene transcription study. Metallomics. 2011;3(11):1199–211.
dos Santos T, Varela J, Lynch I, Salvati A, Dawson KA. Quantitative assessment of the comparative nanoparticle-uptake efficiency of a range of cell lines. Small. 2011;7(23):3341–9.
Chen M, von Mikecz A. Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles. Exp Cell Res. 2005;305(1):51–62.
Sen B, Mahadevan B, DeMarini DM. Transcriptional responses to complex mixtures: a review. Mutat Res. 2007;636(1–3):144–77.
Rouse RL, Murphy G, Boudreaux MJ, Paulsen DB, Penn AL. Soot nanoparticles promote biotransformation, oxidative stress, and inflammation in murine lungs. Am J Respir Cell Mol Biol. 2008;39(2):198–207.
Fujita K, Horie M, Kato H, et al. Effects of ultrafine TiO2 particles on gene expression profile in human keratinocytes without illumination: involvement of extracellular matrix and cell adhesion. Toxicol Lett. 2009;191(2–3):109–17.
Inoue K, Takano H, Ohnuki M, et al. Size effects of nanomaterials on lung inflammation and coagulatory disturbance. Int J Immunopathol Pharmacol. 2008;21(1):197–206.
Waters KM, Masiello LM, Zangar RC, et al. Macrophage responses to silica nanoparticles are highly conserved across particle sizes. Toxicol Sci. 2009;107(2):553–69.
Fujita K, Morimoto Y, Ogami A, et al. Gene expression profiles in rat lung after inhalation exposure to C60 fullerene particles. Toxicology. 2009;258(1):47–55.
Ellinger-Ziegelbauer H, Pauluhn J. Pulmonary toxicity of multi-walled carbon nanotubes (Baytubes) relative to alpha-quartz following a single 6 h inhalation exposure of rats and a 3 months post-exposure period. Toxicology. 2009;266(1–3):16–29.
Zollanvari A, Cunningham MJ, Braga-Neto U and Dougherty ER. Analysis and modeling of time-course gene-expression profiles from nanomaterial-exposed primary human epidermal keratinocytes. BMC Bioinformatics. 2009;10 Suppl 11:S10
Yang Y, Qu Y, Lu X. Global gene expression analysis of the effects of gold nanoparticles on human dermal fibroblasts. J Biomed Nanotechnol. 2010;6(3):234–46.
Ma J, Lu X, Huang Y. Genomic analysis of cytotoxicity response to nanosilver in human dermal fibroblasts. J Biomed Nanotechnol. 2011;7(2):263–75.
Hughes TR, Marton MJ, Jones AR, et al. Functional discovery via a compendium of expression profiles. Cell. 2000;102(1):109–26.
Prow TW, Monteiro-Riviere NA, Inman AO, et al. Quantum dot penetration into viable human skin. Nanotoxicology. 2012;6(2):173–85.
Xia XR, Monteiro-Riviere NA, Riviere JE. Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents. Toxicol Appl Pharmacol. 2010;242(1):29–37.
Warheit DB, Webb TR, Reed KL, Frerichs S, Sayes CM. Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: differential responses related to surface properties. Toxicology. 2007;230(1):90–104.
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Veranth, J.M., Leachman, S.A., Moos, P.J. (2013). Toxicogenomic Evaluation of Nanomaterials. In: Nasir, A., Friedman, A., Wang, S. (eds) Nanotechnology in Dermatology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5034-4_23
Download citation
DOI: https://doi.org/10.1007/978-1-4614-5034-4_23
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-5033-7
Online ISBN: 978-1-4614-5034-4
eBook Packages: MedicineMedicine (R0)