Abstract
Primary hyperparathyroidism (PHPT) is a common condition affecting approximately 100,000 new patients each year in the USA [1]. An apparent increase in the incidence was traced to the wide availability and the use of multichannel analyzers for routine testing. This has resulted in the early detection of subclinical disease since 1970[2]. The technological advancement in multichannel analyzers and the easy availability of biochemical testing have changed the disease presentation of PTHP. The majority of subjects presents well before onset of symptoms or end organ damage. In more than 85 % of these cases, a solitary adenoma is the cause of the problem. Accurate localization of the adenoma enables minimally invasive surgery to be performed, often as an outpatient surgery or with shortened hospitalization and recuperative times [3].
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References
Kebebew E, Clark OH. Parathyroid adenoma, hyperplasia and carcinoma: localization, technical details of primary neck exploration and treatment of hypercalcemic crisis. Surg Oncol Clin N Am. 1998;7:721–48.
Heath III H, Hodgson SF, Kennedy M. Primary hyperparathyroidism: incidence, morbidity and potential economic impact in a community. N Engl J Med. 1980;302:189–93.
Udelsman R, Donovan PI. Open minimally invasive parathyroid surgery. World J Surg. 2004;28(12):1224–6.
Owen R. On the anatomy of the Indian Rhinoceros (Rh. Unicornis L.). Trans Zool Soc Lond. 1862;4:31–58.
Gilmore JR. The gross anatomy of parathyroid glands. J Pathol. 1938;46:133.
Alveryd A. Parathyroid glands in thyroid surgery. Acta Chir Scand. 1968;389:1.
Wang CA, Mahaffey JE, Axelrod L, et al. Hyperfunctioning supernumerary parathyroid glands. Surg Gynecol Obstet. 1979;148:711.
Akerstrom G, Malmaeus J, Bergstrom R. Surgical anatomy of human parathyroid glands. Surgery. 1984;95:14.
Cheung K, Wang TS, Farrokhyar F, Roman SA, Sosa JA. A meta-analysis of preoperative localization techniques for patients with primary hyperparathyroidism. Ann Surg Oncol. 2012;19(2):577–83.
Yeh MW, Barraclough BM, Sidhu SB, Sywak MS, Barraclough BH, Delbridge LW. Two hundred consecutive parathyroid ultrasound studies by a single clinician: the impact of experience. Endocr Pract. 2006;12(3):257–63.
Andre V, Andre M, Le Dreff P, Granier H, Forlodou P, Garcia JF. Intrathyroid parathyroid adenoma. J Radiol. 1999;80(6):591–2.
McIntyre Jr R, Eisenach J, Pearlman N, Ridgeway C, Dale Liechty R. Intrathyroidal parathyroid glands can be a cause of failed cervical exploration for hyperparathyroidism. Am J Surg. 1997;174(6):750–4.
Kamaya A, Quon A, Jeffrey RB. Sonography of the abnormal parathyroid gland. Ultrasound Q. 2006;22(4):253–62.
Lane MJ, Desser TS, Weigel RJ, Jeffrey Jr RB. Use of color and power Doppler sonography to identify feeding arteries associated with parathyroid adenomas. AJR Am J Roentgenol. 1998;171(3):819–23.
Wolf RJ, Cronan JJ, Monchik JM. Color Doppler sonography: an adjunctive technique in assessment of parathyroid adenomas. J Ultrasound Med. 1994;13(4):303–8.
Harari A, Mitmaker E, Grogan RH, Lee J, Shen W, Gosnell J, et al. Primary hyperparathyroidism patients with positive preoperative sestamibi scan and negative ultrasound are more likely to have posteriorly located upper gland adenomas (PLUGs). Ann Surg Oncol. 2011;18(6):1717–22.
Pesenti M, Frasoldati A, Azzarito C, Valcavi R. Parathyroid incidentaloma discovered during thyroid ultrasound imaging. J Endocrinol Invest. 1999;22(10):796–9.
Frasoldati A, Pesenti M, Toschi E, Azzarito C, Zini M, Valcavi R. Detection and diagnosis of parathyroid incidentalomas during thyroid sonography. J Clin Ultrasound. 1999;27(9):492–8.
Doppman JL, Krudy AG, Marx SJ, Saxe A, Schneider P, Norton JA, et al. Aspiration of enlarged parathyroid glands for parathyroid hormone assay. Radiology. 1983;148(1):31–5.
Abraham D, Sharma PK, Bentz J, Gault PM, Neumayer L, McClain DA. The utility of ultrasound guided FNA of parathyroid adenomas for pre-operative localization prior to minimally invasive parathyroidectomy. Endocr Pract. 2007;13(4):333–7.
Norman J, Politz D, Browarski E. Diagnostic aspiration of parathyroid adenomas causes severe fibrosis complicating surgery and final histologic diagnosis. Thyroid. 2007;17(12):1251–5.
Abraham D, Duick AS, Baskin HJ. Appropriate administration of fine-needle aspiration (FNA) biopsy on selective parathyroid adenomas is safe. Thyroid. 2008;18(5):581–2.
Agarwal AM, Bentz JS, Hungerford R, Abraham D. Parathyroid fine-needle aspiration cytology in the evaluation of parathyroid adenoma: cytologic findings from 53 patients. Diagn Cytopathol. 2009;37:407–10.
Krause UC, Friedrich JH, Olbricht T, Metz K. Association of primary hyperparathyroidism and non-medullary thyroid cancer. Eur J Surg. 1996;162(9):685–9.
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Abraham, D. (2013). Ultrasonography of the Parathyroid Glands. In: Baskin, Sr., H., Duick, D., Levine, R. (eds) Thyroid Ultrasound and Ultrasound-Guided FNA. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4785-6_9
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DOI: https://doi.org/10.1007/978-1-4614-4785-6_9
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