Skip to main content
SpringerLink
Log in

Where Do We Go From Here?

  • Chapter
  • First Online:
Doves, Diplomats, and Diabetes

  • 956 Accesses

Abstract

A famous musician was once asked how he visualized music after 20 years. He replied, “If I knew, I will be playing it today!”

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Lindqvist P, Grennert L, Maršál K (1999) Epidermal growth factor in maternal urine—a predictor of intrauterine growth restriction? Early Hum Dev 56:143–150

    Article  PubMed  CAS  Google Scholar 

  2. Kamei Y et al (1999) Maternal epidermal growth factor deficiency causes fetal hypoglycemia and intrauterine growth retardation in mice: possible involvement of placental glucose transporter GLUT3 expression. Endocrinology 140:4236–4243

    Article  PubMed  CAS  Google Scholar 

  3. Cain MP, Kramer SA, Tindall DJ, Husmann DA (1994) Alterations in maternal epidermal growth factor (EGF) effect testicular descent and epididymal development. Urology 43:375–378

    Article  PubMed  CAS  Google Scholar 

  4. Popliker M et al (1987) Onset of endogenous synthesis of epidermal growth factor in neonatal mice. Dev Biol 119:38–44

    Article  PubMed  CAS  Google Scholar 

  5. Kashimata M et al (2000) The ERK-1/2 signaling pathway is involved in the stimulation of branching morphogenesis of fetal mouse submandibular glands by EGF. Dev Biol 220:183–196

    Article  PubMed  CAS  Google Scholar 

  6. Ahrén B, Holst JJ (2001) The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. Diabetes 50:1030–1038

    Article  PubMed  Google Scholar 

  7. Kopf SR, Baratti CM (1999) Effects of posttraining administration of insulin on retention of a habituation response in mice: participation of a central cholinergic mechanism. Neurobiol Learn Mem 71:50–61

    Article  PubMed  CAS  Google Scholar 

  8. Dhingra D, Parle M, Kulkarni SK (2003) Effect of combination of insulin with dextrose, D(−) fructose and diet on learning and memory in mice. Indian J Pharmacol 35:151–156

    CAS  Google Scholar 

  9. Belsare PV et al (2010) Metabolic syndrome: aggression control mechanisms gone out of control. Med Hypotheses 74:578–589

    Article  PubMed  CAS  Google Scholar 

  10. Schaan BD et al (2005) Sympathetic modulation of the renal glucose transporter GLUT2 in diabetic rats. Auton Neurosci 117:54–61

    Article  PubMed  CAS  Google Scholar 

  11. Knauf C et al (2008) Brain glucagon-like peptide 1 signaling controls the onset of high-fat diet-induced insulin resistance and reduces energy expenditure. Endocrinology 149:4768–4777

    Article  PubMed  CAS  Google Scholar 

  12. Knauf C et al (2005) Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. J Clin Invest 115:3554–3563

    Article  PubMed  CAS  Google Scholar 

  13. Darleen S (2008) CNS GLP-1 regulation of peripheral glucose homeostasis. Physiol Behav 94:670–674

    Article  Google Scholar 

  14. Klockener T et al (2011) High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat Neurosci 14:911–918

    Article  PubMed  Google Scholar 

  15. Könner AC et al (2007) Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab 5:438–449

    Article  PubMed  Google Scholar 

  16. Lautt WW (2004) A new paradigm for diabetes and obesity: the hepatic insulin sensitizing substance (HISS) hypothesis. J Pharmacol Sci 95:9–17

    Article  PubMed  CAS  Google Scholar 

  17. Chowdhury KK, Legare DJ, Lautt WW (2011) Insulin sensitization by voluntary exercise in aging rats is mediated through hepatic insulin sensitizing substance (HISS). Exp Gerontol 46:73–80

    Article  PubMed  CAS  Google Scholar 

  18. Bosch G, Beerda B, van der Poel AFB, Hendriks WH (2007) Properties of food that may modulate canine and feline behaviour. Engormix.com (June 21, 2007). http://en.engormix.com/

  19. Albert DJ, Walsh ML, Jonik RH (1993) Aggression in humans: what is its biological foundation? Neurosci Biobehav Rev 17:405–425

    Article  PubMed  CAS  Google Scholar 

  20. Lundberg U et al (1983) Hirsute women with elevated androgen levels: psychological characteristics, steroid hormones, and catecholamines. J Psychosomat Obstet Gynecol 2:86–93

    Article  Google Scholar 

  21. Mann MA, Svare B (1983) Prenatal testosterone exposure elevates maternal aggression in mice. Physiol Behav 30:503–507

    Article  PubMed  CAS  Google Scholar 

  22. Bruce S (1980) Testosterone propionate inhibits maternal aggression in mice. Physiol Behav 24:435–439

    Article  Google Scholar 

  23. Ashcroft GS et al (1997) Estrogen accelerates cutaneous wound healing associated with an increase in TGF-[β]1 levels. Nat Med 3:1209–1215

    Article  PubMed  CAS  Google Scholar 

  24. Ashcroft GS, Greenwell-Wild T, Horan MA, Wahl SM, Ferguson MWJ (1999) Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response. Am J Pathol 155:1137–1146

    Article  PubMed  CAS  Google Scholar 

  25. Ashcroft GS et al (2003) Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. J Clin Invest 111:1309–1318

    PubMed  CAS  Google Scholar 

  26. Hardman MJ, Emmerson E, Campbell L, Ashcroft GS (2008) Selective estrogen receptor modulators accelerate cutaneous wound healing in ovariectomized female mice. Endocrinology 149:551–557

    Article  PubMed  CAS  Google Scholar 

  27. Contreras JL, Smyth CA, Bilbao G, Young CJ, Thompson JA, Eckhoff DE (2002) 17[β]-Estradiol protects isolated human pancreatic islets against proinflammatory cytokine-induced cell death: molecular mechanisms and islet functionality. Transplantation 74:1252–1259

    Article  PubMed  CAS  Google Scholar 

  28. Matute ML, Kalkhoff RK (1973) Sex steroid influence on hepatic gluconeogenesis and glycogen formation. Endocrinology 92:762–768

    Article  PubMed  CAS  Google Scholar 

  29. Rashidi A, Kirkwood TBL, Shanley DP (2009) Metabolic evolution suggests an explanation for the weakness of antioxidant defences in β-cells. Mech Ageing Dev 130:216–221

    Article  PubMed  CAS  Google Scholar 

  30. Rashidi A, Kirkwood TBL, Shanley DP (2009) On the surprising weakness of pancreatic Β-cell antioxidant defences: an evolutionary perspective. In: Pontarotti P (ed) Evolutionary biology. Springer, Heidelberg, pp 109–125

    Chapter  Google Scholar 

  31. Houle D (2009) Colloquium paper: numbering the hairs on our heads: the shared challenge and promise of phenomics. Proc Natl Acad Sci USA 107:1793–1799

    Article  PubMed  Google Scholar 

  32. Tierney E et al (2006) Abnormalities of cholesterol metabolism in autism spectrum disorders. Am J Med Genet B Neuropsychiatr Genet 141B:666–668

    Article  PubMed  Google Scholar 

  33. Aneja A, Tierney E (2008) Autism: the role of cholesterol in treatment. Int Rev Psychiatry 20:165–170

    Article  PubMed  Google Scholar 

  34. Sikora DM, Pettit-Kekkel K, Penfield J, Merkens LS, Steiner RD (2006) The near universal presence of autism spectrum disorders in children with Smith–Lemli–Opitz syndrome. Am J Med Genet A 140A:1511–1518

    Article  Google Scholar 

  35. Clark-Taylor T (2004) Is autism a disorder of fatty acid metabolism? Possible dysfunction of mitochondrial β-oxidation by long chain acyl-CoA dehydrogenase. Med Hypotheses 62:970–975

    Article  PubMed  CAS  Google Scholar 

  36. Corbett BA, Schupp CW, Levine S, Mendoza S (2009) Comparing cortisol, stress, and sensory sensitivity in children with autism. Autism Res 2:39–49

    Article  PubMed  Google Scholar 

  37. Marinović-Ćurin J et al (2007) Slower cortisol response during ACTH stimulation test in autistic children. Eur Child Adolesc Psychiatry 17:39–43

    Article  PubMed  Google Scholar 

  38. Tordjman S et al (1997) Plasma β‐endorphin, adrenocorticotropin hormone, and cortisol in autism. J Child Psychol Psychiatr 38:705–715

    Article  CAS  Google Scholar 

  39. Marinovic Curin J et al (2010) Lower cortisol and higher ACTH levels in individuals with autism. J Autism Dev Disord 33:443–448

    Article  Google Scholar 

  40. Jager J et al (2005) Effects of short‐term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo‐controlled trial. J Intern Med 257:100–109

    Article  PubMed  Google Scholar 

  41. Katakam PVG, Ujhelyi MR, Hoenig M, Miller AW (2000) Metformin improves vascular function in insulin-resistant rats. Hypertension 35:108–112

    Article  PubMed  CAS  Google Scholar 

  42. Majithiya JB, Balaraman R (2006) Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats. Life Sci 78:2615–2624

    Article  PubMed  CAS  Google Scholar 

  43. Diamanti-Kandarakis E et al (2005) Metformin administration improves endothelial function in women with polycystic ovary syndrome. Eur J Endocrinol 152:749–756

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Indian Institute of Science Education and Research Pune (IISER-P), Pune, India

    Milind Watve

Authors
  1. Milind Watve
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media New York

About this chapter

Cite this chapter

Watve, M. (2012). Where Do We Go From Here?. In: Doves, Diplomats, and Diabetes. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4409-1_15

Download citation

Publish with us

Policies and ethics

Search

Navigation