Abstract
Epidemiological and experimental data strongly suggest that type 1 diabetes occurs as a detrimental combination of genetic predisposition and environmental triggering factors. Viruses have been implicated in the etiology of type 1 diabetes as environmental triggers due to epidemiological association as well as by direct isolation from pancreatic type 1 diabetes patients. The concept of virus-induced type 1 diabetes has been used as an experimental basis in several mouse models. Studies are reviewed on how virus-induced animal models have helped to understand the mechanisms of the pathogenesis of autoimmune-mediated diabetes. We intend to review how such findings obtained from animal models have helped to design novel therapeutic interventions for type 1 diabetes.
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Christen, U., von Herrath, M.G. (2013). Virus-Induced Models for Type 1 Diabetes in Mice. In: Taylor, K., Hyöty, H., Toniolo, A., Zuckerman, A. (eds) Diabetes and Viruses. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4051-2_25
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DOI: https://doi.org/10.1007/978-1-4614-4051-2_25
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