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Fulminant Type 1 Diabetes in Japan

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Diabetes and Viruses

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Abstract

Fulminant type 1 diabetes is a novel subtype within type 1 diabetes ­characterized by a remarkably abrupt onset, absence of islet-related autoantibodies, and almost no C-peptide secretion even at the onset of the disease. Several lines of evidence suggest that viral infection contributes to the development of fulminant type 1 diabetes: (1) preceding influenza-like symptoms, (2) elevated IgA level to the enterovirus common antigen, (3) association of HLA-B*4002, (4) several patients with an elevation of antiviral antibodies, (5) TLR expression in the pancreas of patients, and (6) detection of enterovirus or cytomegalovirus in the pancreas of patients.

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Acknowledgments

This study was supported in part by a Grant-in Aid from the Japanese Society for the Promotion of Science (Kakenhi), a grant from a Health and Labour Sciences Research Grant on Research on Intractable Diseases from the Japanese Ministry of Health, Labour and Welfare, a grant from the Japan Medical Association and continuous support of the Japan Diabetes Society.

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Authors and Affiliations

  1. Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, 565-0871, Japan

    Akihisa Imagawa M.D., Ph.D.

  2. Department of Internal Medicine (I), Osaka Medical College, Takatsuki, 569-8686, Japan

    Toshiaki Hanafusa M.D., Ph.D.

Authors
  1. Akihisa Imagawa M.D., Ph.D.
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  2. Toshiaki Hanafusa M.D., Ph.D.
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Corresponding author

Correspondence to Akihisa Imagawa M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Queen Mary's School of Medicine and Dent, Centre for Diabetes & Metabolic Medicine, Institute of Cell & Molecular Science, n/a, London, E1 2AT, United Kingdom

    Keith Taylor

  2. Tampere University Hospital, Department of Virology, University of Tampere, n/a, Tampere, 33520, Finland

    Heikki Hyöty

  3. University of Insubria & Ospedale di Cir, Varese, Italy

    Antonio Toniolo

  4. University College London Medical School, n/a, London, NW3 2PF, United Kingdom

    Arie J. Zuckerman

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Imagawa, A., Hanafusa, T. (2013). Fulminant Type 1 Diabetes in Japan. In: Taylor, K., Hyöty, H., Toniolo, A., Zuckerman, A. (eds) Diabetes and Viruses. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4051-2_22

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